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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8(+) T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell function and fate remains elusive. We found that genetic...

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Detalles Bibliográficos
Autores principales:	Wenes, Mathias, Jaccard, Alison, Wyss, Tania, Maldonado-Pérez, Noelia, Teoh, Shao Thing, Lepez, Anouk, Renaud, Fabrice, Franco, Fabien, Waridel, Patrice, Yacoub Maroun, Céline, Tschumi, Benjamin, Dumauthioz, Nina, Zhang, Lianjun, Donda, Alena, Martín, Francisco, Migliorini, Denis, Lunt, Sophia Y., Ho, Ping-Chih, Romero, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116152/ https://www.ncbi.nlm.nih.gov/pubmed/35452600 http://dx.doi.org/10.1016/j.cmet.2022.03.013

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