Cargando…

Mutations of the nACh Receptor M4 Helix Reveal Different Phenotypes in Different Expression Systems: Could Lipids be Responsible?

The role of the outermost helix (M4) in the pentameric ligand-gated ion channel (pLGIC) family is currently not fully understood. It is known that M4 is important for receptor assembly, possibly via interactions with neighboring M1 and M3 helices. M4 can also transmit information on the lipid conten...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mesoy, Susanne M., Bridgland-Taylor, Matthew, Lummis, Sarah C. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116227/ https://www.ncbi.nlm.nih.gov/pubmed/35600303 http://dx.doi.org/10.3389/fphys.2022.850782

Ejemplares similares

A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism
por: Crnjar, Alessandro, et al.
Publicado: (2021)

Residues in the 1st Transmembrane-Spanning Helix Are Important for GABA(A)ρ Receptor Function
por: Crowther, Kate M., et al.
Publicado: (2022)

5-HT(3) Receptor MX Helix Contributes to Receptor Function
por: Mocatta, James, et al.
Publicado: (2022)

The binding orientation of epibatidine at α7 nACh receptors
por: Thompson, Andrew J., et al.
Publicado: (2017)

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
por: Loser, Dominik, et al.
Publicado: (2021)

The α7nACh–NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking
por: Li, Shupeng, et al.
Publicado: (2012)

Dietary Different Replacement Levels of Fishmeal by Fish Silage Could Influence Growth of Litopenaeus vannamei by Regulating mTOR at Transcriptional Level
por: Shao, Jianchun, et al.
Publicado: (2020)

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking
por: Rudell, Jolene Chang, et al.
Publicado: (2020)

PT667. Nicotine evokes convulsive seizures by activating amygdala neurons partly through α7nACh receptors
por: Iha, Higor A., et al.
Publicado: (2016)

Helix-helix interactions inside lipid bilayers
por: Lemmon, Mark A., et al.
Publicado: (1992)

Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2
por: Hall, Allison R., et al.
Publicado: (2018)

Distinct functional roles for the M4 α-helix from each homologous subunit in the heteropentameric ligand-gated ion channel nAChR
por: Thompson, Mackenzie J., et al.
Publicado: (2022)

Gene Mutations Resulting in the Development of ARVC/D Could Affect Cells of the Cardiac Conduction System
por: Pieperhoff, Sebastian
Publicado: (2012)

The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism – A Systems Biology Analysis Using Self-Organizing Maps
por: Rennert, Christiane, et al.
Publicado: (2018)

Transmembrane TM3b of Mechanosensitive Channel MscS Interacts With Cytoplasmic Domain Cyto-Helix
por: Wang, Xiaomin, et al.
Publicado: (2018)

The Exposure to Different Photoperiods Strongly Modulates the Glucose and Lipid Metabolisms of Normoweight Fischer 344 Rats
por: Mariné-Casadó, Roger, et al.
Publicado: (2018)

The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis
por: Hu, Song, et al.
Publicado: (2021)

Select Skeletal Muscle mRNAs Related to Exercise Adaptation Are Minimally Affected by Different Pre-exercise Meals that Differ in Macronutrient Profile
por: Knuiman, Pim, et al.
Publicado: (2018)

Could magnetic resonance provide in vivo histology?
por: Dominietto, Marco, et al.
Publicado: (2014)

A Fluid–Structure Interaction Study of Different Bicuspid Aortic Valve Phenotypes Throughout the Cardiac Cycle
por: Yan, Wentao, et al.
Publicado: (2021)

Myokarditis nach mRNA-Impfung
por: Formanek, Anna, et al.
Publicado: (2022)

The Association Between Physical Activity and Insulin Level Under Different Levels of Lipid Indices and Serum Uric Acid
por: Lin, Yajuan, et al.
Publicado: (2022)

Changes in the Distribution of Membrane Lipids during Growth of Thermotoga maritima at Different Temperatures: Indications for the Potential Mechanism of Biosynthesis of Ether-Bound Diabolic Acid (Membrane-Spanning) Lipids
por: Sahonero-Canavesi, Diana X., et al.
Publicado: (2022)

Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells
por: Liu, Yi-qing, et al.
Publicado: (2017)

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations
por: Pioner, Josè Manuel, et al.
Publicado: (2022)

The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes
por: Xu, Manyu, et al.
Publicado: (2017)

Patient-Specific Modeling Could Predict Occurrence of Pediatric Stroke
por: Horn, John D., et al.
Publicado: (2022)

Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP(2) Interaction
por: Tran, Baouyen, et al.
Publicado: (2020)

Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus
por: Tsuchida, Yasuaki, et al.
Publicado: (2010)

Erratum to: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes
por: Xu, Manyu, et al.
Publicado: (2017)

Balancing Force Field Protein–Lipid Interactions To Capture Transmembrane Helix–Helix Association
por: Domański, Jan, et al.
Publicado: (2018)

The Bodies in Charge of Animal Welfare: What They Do and What They Could Do?
por: Grignaschi, Giuliano, et al.
Publicado: (2018)

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene
por: D'Adamo, Maria C., et al.
Publicado: (2015)

The Impact of Different Environmental Conditions on Cognitive Function: A Focused Review
por: Taylor, Lee, et al.
Publicado: (2016)

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
por: Lin, Bo, et al.
Publicado: (2016)

An Integrated Analysis of miRNAs and Methylated Genes Encoding mRNAs and lncRNAs in Sheep Breeds with Different Fecundity
por: Miao, Xiangyang, et al.
Publicado: (2017)

Transcriptome analysis of mRNAs, lncRNAs, and miRNAs in the skeletal muscle of Tibetan chickens at different developmental stages
por: Li, Jie, et al.
Publicado: (2023)

A Divergent Selection on Breast Meat Ultimate pH, a Key Factor for Chicken Meat Quality, is Associated With Different Circulating Lipid Profiles
por: Beauclercq, Stéphane, et al.
Publicado: (2022)

Lineage-specific mutation of Lmx1b provides new insights into distinct regulation of suture development in different areas of the calvaria
por: Cabrera Pereira, Angel, et al.
Publicado: (2023)

Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?
por: Eleazu, Chinedum, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_abc89g1u7fdqprvmjg6pqm7mej