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Mutations of the nACh Receptor M4 Helix Reveal Different Phenotypes in Different Expression Systems: Could Lipids be Responsible?

The role of the outermost helix (M4) in the pentameric ligand-gated ion channel (pLGIC) family is currently not fully understood. It is known that M4 is important for receptor assembly, possibly via interactions with neighboring M1 and M3 helices. M4 can also transmit information on the lipid conten...

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Detalles Bibliográficos
Autores principales:	Mesoy, Susanne M., Bridgland-Taylor, Matthew, Lummis, Sarah C. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116227/ https://www.ncbi.nlm.nih.gov/pubmed/35600303 http://dx.doi.org/10.3389/fphys.2022.850782

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