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Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study

BACKGROUND: Inflammation and immune responses play an important role in the pathophysiology of contrast-associated acute kidney injury (CA-AKI), and systemic immune inflammation index (SII) has recently emerged as a new parameter for immune and inflammatory response evaluation. However, limited rese...

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Autores principales: Lai, Wenguang, Zhao, Xiaoli, Huang, Zhidong, Xie, Yun, Yu, Sijia, Tu, Jiabin, Guo, Dachuan, Xiu, Jiaming, Mai, Ziling, Li, Qiang, Huang, Haozhang, Li, Huanqiang, Xu, Jun-Yan, Lu, Hongyu, Chen, Guanzhong, Chen, Shiqun, Liu, Jin, Liu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116410/
https://www.ncbi.nlm.nih.gov/pubmed/35602662
http://dx.doi.org/10.2147/JIR.S364915
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author Lai, Wenguang
Zhao, Xiaoli
Huang, Zhidong
Xie, Yun
Yu, Sijia
Tu, Jiabin
Guo, Dachuan
Xiu, Jiaming
Mai, Ziling
Li, Qiang
Huang, Haozhang
Li, Huanqiang
Xu, Jun-Yan
Lu, Hongyu
Chen, Guanzhong
Chen, Shiqun
Liu, Jin
Liu, Yong
author_facet Lai, Wenguang
Zhao, Xiaoli
Huang, Zhidong
Xie, Yun
Yu, Sijia
Tu, Jiabin
Guo, Dachuan
Xiu, Jiaming
Mai, Ziling
Li, Qiang
Huang, Haozhang
Li, Huanqiang
Xu, Jun-Yan
Lu, Hongyu
Chen, Guanzhong
Chen, Shiqun
Liu, Jin
Liu, Yong
author_sort Lai, Wenguang
collection PubMed
description BACKGROUND: Inflammation and immune responses play an important role in the pathophysiology of contrast-associated acute kidney injury (CA-AKI), and systemic immune inflammation index (SII) has recently emerged as a new parameter for immune and inflammatory response evaluation. However, limited research has been undertaken to explore the relationship between SII and CA-AKI following coronary angiography (CAG). PATIENTS AND METHODS: From January 2007 to December 2020, 46,333 patients undergoing CAG were included from 5 Chinese tertiary hospitals. SII was calculated as total peripheral platelets count × neutrophil-to-lymphocyte ratio. Patients were categorized by preprocedural SII quartiles: Q1 ≤404.5, Q2 >404.5 and ≤631.7, Q3 >631.7 and ≤1082.8, Q4 >1082.8. Univariable and multivariable logistic regression were used to reveal the link between preprocedural SII and CA-AKI. RESULTS: A total of the 46,333 patients (62.9 ± 11.5 years, female 28.1%) were included in the study. The incidence of CA-AKI was 8.4% in Q1 group, 8.7% in Q2 group, 9.4% in Q3 group, 15.1% in Q4 group. In the multivariable model, comparing the highest (Q4 group) to lowest (Q1 group) SII level categories, preprocedural SII was related to a higher risk of CA-AKI after fully adjusting for well-known confounders, and there was no statistically difference in the other two SII level categories (Q2 and Q3 groups) compared with Q1 group (adjusted model 3: Q2 group: OR: 0.98, 95% CI: 0.87–1.11, P = 0.771; Q3 group: OR: 1.04, 95% CI: 0.92–1.18, P = 0.553; Q4: OR: 1.65, 95% CI: 1.45–1.88, p < 0.001; P for trend < 0.001). Similar results were found for all the subgroups analysis except for patients undergoing PCI, and the interaction analyses for age, PCI and AMI were significant. In addition, Kaplan–Meier curves demonstrated that the lowest quartile group showed the worst all-cause mortality in a significant SII level-dependent manner among the four groups (Log rank test; p < 0.0001). CONCLUSION: Elevated preprocedural SII level was a significant and independent risk factor for CA-AKI following CAG. Higher-quality prospective studies are needed to validate the predictive value of SII for CA-AKI.
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spelling pubmed-91164102022-05-19 Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study Lai, Wenguang Zhao, Xiaoli Huang, Zhidong Xie, Yun Yu, Sijia Tu, Jiabin Guo, Dachuan Xiu, Jiaming Mai, Ziling Li, Qiang Huang, Haozhang Li, Huanqiang Xu, Jun-Yan Lu, Hongyu Chen, Guanzhong Chen, Shiqun Liu, Jin Liu, Yong J Inflamm Res Original Research BACKGROUND: Inflammation and immune responses play an important role in the pathophysiology of contrast-associated acute kidney injury (CA-AKI), and systemic immune inflammation index (SII) has recently emerged as a new parameter for immune and inflammatory response evaluation. However, limited research has been undertaken to explore the relationship between SII and CA-AKI following coronary angiography (CAG). PATIENTS AND METHODS: From January 2007 to December 2020, 46,333 patients undergoing CAG were included from 5 Chinese tertiary hospitals. SII was calculated as total peripheral platelets count × neutrophil-to-lymphocyte ratio. Patients were categorized by preprocedural SII quartiles: Q1 ≤404.5, Q2 >404.5 and ≤631.7, Q3 >631.7 and ≤1082.8, Q4 >1082.8. Univariable and multivariable logistic regression were used to reveal the link between preprocedural SII and CA-AKI. RESULTS: A total of the 46,333 patients (62.9 ± 11.5 years, female 28.1%) were included in the study. The incidence of CA-AKI was 8.4% in Q1 group, 8.7% in Q2 group, 9.4% in Q3 group, 15.1% in Q4 group. In the multivariable model, comparing the highest (Q4 group) to lowest (Q1 group) SII level categories, preprocedural SII was related to a higher risk of CA-AKI after fully adjusting for well-known confounders, and there was no statistically difference in the other two SII level categories (Q2 and Q3 groups) compared with Q1 group (adjusted model 3: Q2 group: OR: 0.98, 95% CI: 0.87–1.11, P = 0.771; Q3 group: OR: 1.04, 95% CI: 0.92–1.18, P = 0.553; Q4: OR: 1.65, 95% CI: 1.45–1.88, p < 0.001; P for trend < 0.001). Similar results were found for all the subgroups analysis except for patients undergoing PCI, and the interaction analyses for age, PCI and AMI were significant. In addition, Kaplan–Meier curves demonstrated that the lowest quartile group showed the worst all-cause mortality in a significant SII level-dependent manner among the four groups (Log rank test; p < 0.0001). CONCLUSION: Elevated preprocedural SII level was a significant and independent risk factor for CA-AKI following CAG. Higher-quality prospective studies are needed to validate the predictive value of SII for CA-AKI. Dove 2022-05-13 /pmc/articles/PMC9116410/ /pubmed/35602662 http://dx.doi.org/10.2147/JIR.S364915 Text en © 2022 Lai et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Lai, Wenguang
Zhao, Xiaoli
Huang, Zhidong
Xie, Yun
Yu, Sijia
Tu, Jiabin
Guo, Dachuan
Xiu, Jiaming
Mai, Ziling
Li, Qiang
Huang, Haozhang
Li, Huanqiang
Xu, Jun-Yan
Lu, Hongyu
Chen, Guanzhong
Chen, Shiqun
Liu, Jin
Liu, Yong
Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
title Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
title_full Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
title_fullStr Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
title_full_unstemmed Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
title_short Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
title_sort elevation of preprocedural systemic immune inflammation level increases the risk of contrast-associated acute kidney injury following coronary angiography: a multicenter cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116410/
https://www.ncbi.nlm.nih.gov/pubmed/35602662
http://dx.doi.org/10.2147/JIR.S364915
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