Hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy

CRISPR-Cas13a holds enormous potential for developing precise RNA editing. However, spatial manipulation of CRISPR-Cas13a activity remains a daunting challenge for elaborately regulating localized RNase function. Here, we designed hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons...

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Detalles Bibliográficos
Autores principales: Fan, Ningke, Bian, Xintong, Li, Meng, Chen, Junman, Wu, Haiping, Peng, Qiling, Bai, Huijie, Cheng, Wenqian, Kong, Liangsheng, Ding, Shijia, Li, Siqiao, Cheng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116607/
https://www.ncbi.nlm.nih.gov/pubmed/35584220
http://dx.doi.org/10.1126/sciadv.abn7382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116607/
https://www.ncbi.nlm.nih.gov/pubmed/35584220
http://dx.doi.org/10.1126/sciadv.abn7382

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