Abstract No. : ABS0510: Total intravenous anaesthesia (TIVA) with dexmedetomidine versus nalbuphine in combination with propofol in upperlimb orthopaedic closed manipulation procedure- a comparative study in a tertiary health care centre in Tripura.

BACKGROUND &AIMS: The study was planned with the aim of generating comparison profile regarding effects of dexmedetomidine and nalbuphine in combination with propofol while providing more effective stability of intra-procedural haemodynamics and post procedural pain and sedation in upperlimb closed manipulation procedure. METHODS: It was an observational analytical study with longitudinal design. The study duration was one and half years. Patients of either sex, normalbodymassindexand age between 20-60 years participatedas study population. 60 cases weredevided into two groups and coded as group D and group N. Both the groups received uniform premedication with Injodansertron 8mg I.V and Inj. omeprazole 40 mg I.V. Group D received Inj. propofol (1%) 1.5mg/kg plus Inj. dexmedetomidine 50 µg I.V bolus while group N received inj. propofol (1%) 1.5mg/kg plus Inj. nalbuphine 10mg I.V bolus prior to theprocedure. RESULTS: Intra operative mean arterial pressure (MAP) and heart rate (HR) were significantly higher in group N than group D (p<0.05). No significant difference was recorded regarding respiratory rate and SpO(2) in the two groups (p>0.05). Recovery time of orientation was significantly lower in group D (p<0.05). Post procedural perception of pain was significantly lower in group D (p<0.05). Post procedural sedation was lower in group D which was statistically significant (p<0.05). CONCLUSION: Dexmedetomidine is superior to nalbuphine in respect of more effective intra-procedural haemodynamic stability, recovery oforientation , pain control after procedure and control of sedation after procedure.