Abstract No.: ABS0639: A comparison of the total intraoperative fluid administered by goal directed fluid therapy and conventional fluid therapy in isolated traumatic brain injury patients undergoing early decompressive craniectomy- a prospective randomised controlled trial

BACKGROUND & AIMS: Traumatic brain injury patients are prone to osmotic and electrolyte disturbances, hence require a unique approach to fluid management. Primary aim of the study is to compare goal-directed therapy and conventional hemodynamic based therapy on total intra-operative fluid administered during decompressive craniectomy METHODS: Prospective randomised controlled trial was conducted at PGIMER, accruing 64 adult patients with TBI undergoing decompressive craniectomy Goal directed fluid therapy (GDT) used Flo Trac, EV-1000 device (Edwards Lifesciences, Irvine, CA) to monitor Stroke volume variation, Cardiac index and mean arterial pressure Conventional fluid therapyutilisedcrystalloids infused at a rate of 2 ml/kg/hour with target MAP >70 mm of Hg. Quantitative variables were compared using unpaired t test if normally distributed, Mann Whitney U test was used for non-normally distributed quantitative and ordinal data. A P < 0.05 was considered statistically significant. The statistical analysis was done using IBM SPSS version 25. RESULTS: There was a numerical difference in total fluid administered between both the groups but did not prove to be statistically significant (p=0.511). No significant difference in intraoperative blood loss (p=0.776), urine output (p=0.230), total ventilator days (p=0.30), total ICU days (p=0.34), total hospital days (p=0.57) and GCS at discharge (0.53). There was significant difference in levels of hematocrit (p=0.00) and levels of lactate (p=0.00) within both the groups and GCS pre- and post-surgery (p=0.04) CONCLUSION: No statistically significant difference between the total intraoperative fluid administered between both the groups was observed. Quest for methods to improve outcome in traumatic brain injury patients it still ongoing.