Abstract No.: ABS2271: A Comparative Study of Optic Nerve Sheath Diameter and Lung Ultrasound Score in Healthy and Preeclampsia Parturients.

BACKGROUND & AIMS: Complications of preeclampsia include cerebral and pulmonary oedema which strongly correlate with optic nerve sheath diameter (ONSD) and lung ultrasound score (LUSS) respectively. This study was conducted to compare ONSD and LUSS in healthy and preeclamptic parturients. METHODS: In this prospective observational analytical study, healthy pregnant women and preeclamptic women, 35 each, age >18 years and gestational age >34 weeks up to 24 hours of delivery, were included. Approval from institutional ethical committee was obtained and trial registered with clinical trial registry of India. Ultrasound assessment for ONSD and LUSS (12 region lung technique) was performed. Severity of preeclampsia was noted. Data was analysed using appropriate statistical tests. ROC analysis was performed to obtain a cutoff value for both ONSD and LUSS to predict complications of preeclampsia. A p-value of <0.05 was considered significant. RESULTS: Of the 35 preeclamptic women, 19 had severe preeclampsia. Severe preeclamptics had higher ONSD and LUSS than mild preeclamptics and healthy parturients (p-value < 0.001). No difference was observed in LUSS between mild preeclamptics and healthy parturients. Mean ONSD of >4.65mm and LUSS of >2 predicted preeclampsia complications with a sensitivity of 77.14% and 68.57%, specificity of 91.43% and 85.71% and AUC of 0.907 and 0.806 respectively. CONCLUSION: ONSD and LUSS assessment is an easy, bedside, noninvasive technique to assess complications, guide fluid therapy and monitor response to treatment in preeclamptic parturients. Thus, early intervention can help in reducing maternal/fetal morbidity and mortality