Abstract No. : ABS2758: To assess the effect of Dexmedetomidinenebulisation on propofol requirement for induction in laparoscopic tubal ligation- Patient State Index (PSI) guided general anaesthesia

BACKGROUND &AIMS: Laparoscopic tubal ligation is one of the most commonly performed sterilization procedure on a day care basis. This study aims to assess the effectiveness of dexmedetomidinenebulisation on propofol requirement for induction. METHODS: After obtaining ethical committee clearance, A randomiseddouble blind clinical trial was performed on 40 parturients of AmericanSocietyofAnesthesiologists physical status I and II. Theywere posted for laparoscopic tubal ligation under general anaesthesia with spontaneous ventilation using I gel. They were divided into 2 groups. Group D received dexmedetomidinenebulisation 2µg/kg 20min before induction, Group P received saline nebulisation ,both groups were induced with injection propofol to maintainPatient State Index(PSI) in the range of (25-50). Consumption of propofol, heart rate , systolic blood pressure,diastolic blood pressure, mean arterial blood pressure and any incidence of adverse events were noted. RESULTS: The demographic variables were comparable between the two groups. There was significant difference between the mean propofol dose for induction in group D and group P i.e 55.50+/-7.23 and 89+/- 6.40 respectively, with p <0.001 using Mann Whitney U test. Postoperatively, parturients were assessed with Ramsay sedation scale which was statistically not significant. CONCLUSION: Preoperative nebulisation with dexmedetomidine significantly reduces the induction dose of propofol.