Abstract No. : ABS3718: Comparison of ketamine-dexmedetomidine versus ketamine-propofol combination for sedation during short duration urological procedure: A randomised study

BACKGROUND AND AIMS: The present study aimed to compare safety and efficacy of ketamine-dexmedetomidine (KD) with ketamine- Propofol (KP) for sedation during short-duration urological procedure. METHODS: The present study enroled and randomised 60 patients into either of the two groups. In Group KD (n=30) received inj dexmedetomidine 1.0 µ/ kg over 10 minutes intravenously followed by inj. ketamine 1 mg/kg as initial dose followed by 0.25mg/kg in titration. In Group KP (n=30) patients received inj propofol 1mg/kg with inj ketamine 1mg/kg as initial dose followed by the same combination top-up dose 0.25mg/kg in titration. Sedation score, Memorial delirium assessment Scale (MIDS), postoperative pain scores and recovery time were recorded. For Independent-samples, t-test was used and for proportion of significance, Chi-square test was used. RESULTS: Post anaesthesia recovery scores (PARS) were 9.03±0.45 in Group KP and 9.06±0.36 in Group KD, p value= 0.79. No significant differences were observed in the level of sedation, PARS and postoperative pain in both the groups. In Group KD, patients were haemodynamically stable as compared to Group KP. There were no episode of apnea in Group KD as compared 6 episodes in Group KP, (p=0.005). No significant adverse event were reported in both the groups. CONCLUSION: No differences were observed in sedation score and recovery period in both the groups. Patients in Group KD experienced reduced respiratory depression as compared to Group K. Sedation with Ketamine-dexmedetomidine can be considered as a useful alternative to ketamine-propofol in short urological procedures.