Cargando…

Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets

There are rarely new therapeutic breakthroughs present for neurodegenerative diseases in the last decades. Thus, new effective drugs are urgently needed for millions of patients with neurodegenerative diseases. Celastrol, a pentacyclic triterpenoid compound, is one of the main active ingredients iso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Dandan, Zhang, Qian, Luo, Piao, Gu, Liwei, Shen, Shengnan, Tang, Huan, Zhang, Ying, Lyu, Ming, Shi, Qiaoli, Yang, Chuanbin, Wang, Jigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JKL International LLC 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116906/ https://www.ncbi.nlm.nih.gov/pubmed/35656110 http://dx.doi.org/10.14336/AD.2021.1115

Ejemplares similares

Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion
por: Liu, Dan-Dan, et al.
Publicado: (2021)

Unscrambling secretion
por: Tuma, Rabiya S.
Publicado: (2006)

Unscrambling the genome
por: Crossley, Merlin
Publicado: (2003)

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
por: Luo, Piao, et al.
Publicado: (2022)

Unscrambling butterfly oogenesis
por: Carter, Jean-Michel, et al.
Publicado: (2013)

Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics
por: Zhang, Qian, et al.
Publicado: (2022)

Unscrambling phylogenetic effects and ecological determinants of chromosome number in major angiosperm clades
por: Carta, Angelino, et al.
Publicado: (2018)

Super‐Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment
por: Li, Yanping, et al.
Publicado: (2021)

Unscrambling an egg: protein disaggregation by AAA+ proteins
por: Weibezahn, Jimena, et al.
Publicado: (2004)

18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs
por: Zhang, Qian, et al.
Publicado: (2022)

Unscrambling Cyanobacteria Community Dynamics Related to Environmental Factors
por: Bertos-Fortis, Mireia, et al.
Publicado: (2016)

Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics
por: Luo, Piao, et al.
Publicado: (2022)

Platelet concentration in platelet concentrates and periodontal regeneration-unscrambling the ambiguity
por: Suchetha, A., et al.
Publicado: (2015)

Unscrambling light—automatically undoing strong mixing between modes
por: Annoni, Andrea, et al.
Publicado: (2017)

Unscrambling U.S. egg supply chains amid COVID-19()
por: Malone, Trey, et al.
Publicado: (2021)

Neural unscrambling of temporal information during a nonlinear narrative
por: Grall, Clare, et al.
Publicado: (2023)

Unscrambling the relations of egg and meat consumption with type 2 diabetes risk
por: Sabaté, Joan, et al.
Publicado: (2018)

Unscrambling the Provenance of Eggs by Combining Chemometrics and Near-Infrared Reflectance Spectroscopy
por: Hoffman, Louwrens Christiaan, et al.
Publicado: (2022)

Synthesis and characterisation of celastrol derivatives as potential anticancer agents
por: Zhang, Hong-Jian, et al.
Publicado: (2017)

Full of bull: unscramble Wall Street doubletalk to protect and build your portfolio
por: McClellan, Stephen T
Publicado: (2010)

Unscrambling variation in avian eggshell colour and patterning in a continent-wide study
por: L'Herpiniere, Kiara L., et al.
Publicado: (2019)

Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy
por: Platzer, René, et al.
Publicado: (2020)

Unscrambling cancer genomes via integrated analysis of structural variation and copy number
por: Shale, Charles, et al.
Publicado: (2022)

The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease
por: Zhang, Chenyu, et al.
Publicado: (2021)

Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke
por: Hong, Zexuan, et al.
Publicado: (2023)

Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis
por: Xinqiang, Song, et al.
Publicado: (2020)

Celastrol-based nanomedicine promotes corneal allograft survival
por: Li, Zhanrong, et al.
Publicado: (2021)

The Potential Mechanisms of the Neuroprotective Actions of Oil Palm Phenolics: Implications for Neurodegenerative Diseases
por: Ibrahim, Nurul ‘Izzah, et al.
Publicado: (2020)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells
por: Ng, Lam, et al.
Publicado: (2022)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol
por: Pilipović, Kristina, et al.
Publicado: (2023)

Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
por: Li, Zhanrong, et al.
Publicado: (2020)

Corrigendum: Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells
por: Ng, Lam, et al.
Publicado: (2022)

Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
por: Xu, Li-Na, et al.
Publicado: (2019)

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
por: Luo, Piao, et al.
Publicado: (2022)

Formulation and Evaluation of Celastrol-Loaded Liposomes
por: Song, Jie, et al.
Publicado: (2011)

Disease modification and Neuroprotection in neurodegenerative disorders
por: Cummings, Jeffrey
Publicado: (2017)

Correction: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Publicado: (2021)

Exploration of the effect of Celastrol on protein targets in nasopharyngeal carcinoma: Network pharmacology, molecular docking and experimental evaluations
por: Ling, Junjun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3ggcmun5vt144fciktmcogqk5s