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Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment

Because of their ex utero development, relatively simple nervous system, translucency, and availability of tools to investigate neural function, larval zebrafish are an exceptional model for understanding neurodevelopmental disorders and the consequences of environmental toxins. Furthermore, early i...

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Autores principales: Scaramella, Courtney, Alzagatiti, Joseph B., Creighton, Christopher, Mankatala, Samandeep, Licea, Fernando, Winter, Gabriel M., Emtage, Jasmine, Wisnieski, Joseph R., Salazar, Luis, Hussain, Anjum, Lee, Faith M., Mammootty, Asma, Mammootty, Niyaza, Aldujaili, Andrew, Runnberg, Kristine A., Hernandez, Daniela, Zimmerman-Thompson, Trevor, Makwana, Rikhil, Rouvere, Julien, Tahmasebi, Zahra, Zavradyan, Gohar, Campbell, Christopher S., Komaranchath, Meghna, Carmona, Javier, Trevitt, Jennifer, Glanzman, David, Roberts, Adam C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116930/
https://www.ncbi.nlm.nih.gov/pubmed/35508370
http://dx.doi.org/10.1523/ENEURO.0020-22.2022
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author Scaramella, Courtney
Alzagatiti, Joseph B.
Creighton, Christopher
Mankatala, Samandeep
Licea, Fernando
Winter, Gabriel M.
Emtage, Jasmine
Wisnieski, Joseph R.
Salazar, Luis
Hussain, Anjum
Lee, Faith M.
Mammootty, Asma
Mammootty, Niyaza
Aldujaili, Andrew
Runnberg, Kristine A.
Hernandez, Daniela
Zimmerman-Thompson, Trevor
Makwana, Rikhil
Rouvere, Julien
Tahmasebi, Zahra
Zavradyan, Gohar
Campbell, Christopher S.
Komaranchath, Meghna
Carmona, Javier
Trevitt, Jennifer
Glanzman, David
Roberts, Adam C.
author_facet Scaramella, Courtney
Alzagatiti, Joseph B.
Creighton, Christopher
Mankatala, Samandeep
Licea, Fernando
Winter, Gabriel M.
Emtage, Jasmine
Wisnieski, Joseph R.
Salazar, Luis
Hussain, Anjum
Lee, Faith M.
Mammootty, Asma
Mammootty, Niyaza
Aldujaili, Andrew
Runnberg, Kristine A.
Hernandez, Daniela
Zimmerman-Thompson, Trevor
Makwana, Rikhil
Rouvere, Julien
Tahmasebi, Zahra
Zavradyan, Gohar
Campbell, Christopher S.
Komaranchath, Meghna
Carmona, Javier
Trevitt, Jennifer
Glanzman, David
Roberts, Adam C.
author_sort Scaramella, Courtney
collection PubMed
description Because of their ex utero development, relatively simple nervous system, translucency, and availability of tools to investigate neural function, larval zebrafish are an exceptional model for understanding neurodevelopmental disorders and the consequences of environmental toxins. Furthermore, early in development, zebrafish larvae easily absorb chemicals from water, a significant advantage over methods required to expose developing organisms to chemical agents in utero. Bisphenol A (BPA) and BPA analogs are ubiquitous environmental toxins with known molecular consequences. All humans have measurable quantities of BPA in their bodies. Most concerning, the level of BPA exposure is correlated with neurodevelopmental difficulties in people. Given the importance of understanding the health-related effects of this common toxin, we have exploited the experimental advantages of the larval zebrafish model system to investigate the behavioral and anatomic effects of BPA exposure. We discovered that BPA exposure early in development leads to deficits in the processing of sensory information, as indicated by BPA’s effects on prepulse inhibition (PPI) and short-term habituation (STH) of the C-start reflex. We observed no changes in locomotion, thigmotaxis, and repetitive behaviors (circling). Despite changes in sensory processing, we detected no regional or whole-brain volume changes. Our results show that early BPA exposure can induce sensory processing deficits, as revealed by alterations in simple behaviors that are mediated by a well-defined neural circuit.
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spelling pubmed-91169302022-05-19 Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment Scaramella, Courtney Alzagatiti, Joseph B. Creighton, Christopher Mankatala, Samandeep Licea, Fernando Winter, Gabriel M. Emtage, Jasmine Wisnieski, Joseph R. Salazar, Luis Hussain, Anjum Lee, Faith M. Mammootty, Asma Mammootty, Niyaza Aldujaili, Andrew Runnberg, Kristine A. Hernandez, Daniela Zimmerman-Thompson, Trevor Makwana, Rikhil Rouvere, Julien Tahmasebi, Zahra Zavradyan, Gohar Campbell, Christopher S. Komaranchath, Meghna Carmona, Javier Trevitt, Jennifer Glanzman, David Roberts, Adam C. eNeuro Research Article: New Research Because of their ex utero development, relatively simple nervous system, translucency, and availability of tools to investigate neural function, larval zebrafish are an exceptional model for understanding neurodevelopmental disorders and the consequences of environmental toxins. Furthermore, early in development, zebrafish larvae easily absorb chemicals from water, a significant advantage over methods required to expose developing organisms to chemical agents in utero. Bisphenol A (BPA) and BPA analogs are ubiquitous environmental toxins with known molecular consequences. All humans have measurable quantities of BPA in their bodies. Most concerning, the level of BPA exposure is correlated with neurodevelopmental difficulties in people. Given the importance of understanding the health-related effects of this common toxin, we have exploited the experimental advantages of the larval zebrafish model system to investigate the behavioral and anatomic effects of BPA exposure. We discovered that BPA exposure early in development leads to deficits in the processing of sensory information, as indicated by BPA’s effects on prepulse inhibition (PPI) and short-term habituation (STH) of the C-start reflex. We observed no changes in locomotion, thigmotaxis, and repetitive behaviors (circling). Despite changes in sensory processing, we detected no regional or whole-brain volume changes. Our results show that early BPA exposure can induce sensory processing deficits, as revealed by alterations in simple behaviors that are mediated by a well-defined neural circuit. Society for Neuroscience 2022-05-16 /pmc/articles/PMC9116930/ /pubmed/35508370 http://dx.doi.org/10.1523/ENEURO.0020-22.2022 Text en Copyright © 2022 Scaramella et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Scaramella, Courtney
Alzagatiti, Joseph B.
Creighton, Christopher
Mankatala, Samandeep
Licea, Fernando
Winter, Gabriel M.
Emtage, Jasmine
Wisnieski, Joseph R.
Salazar, Luis
Hussain, Anjum
Lee, Faith M.
Mammootty, Asma
Mammootty, Niyaza
Aldujaili, Andrew
Runnberg, Kristine A.
Hernandez, Daniela
Zimmerman-Thompson, Trevor
Makwana, Rikhil
Rouvere, Julien
Tahmasebi, Zahra
Zavradyan, Gohar
Campbell, Christopher S.
Komaranchath, Meghna
Carmona, Javier
Trevitt, Jennifer
Glanzman, David
Roberts, Adam C.
Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment
title Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment
title_full Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment
title_fullStr Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment
title_full_unstemmed Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment
title_short Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment
title_sort bisphenol a exposure induces sensory processing deficits in larval zebrafish during neurodevelopment
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116930/
https://www.ncbi.nlm.nih.gov/pubmed/35508370
http://dx.doi.org/10.1523/ENEURO.0020-22.2022
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