Genetic and chemotherapeutic influences on germline hypermutation

Mutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual’s genome(1,2). Here we analysed the genome-wide sequences of 21,879 families with rare genetic di...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaplanis, Joanna, Ide, Benjamin, Sanghvi, Rashesh, Neville, Matthew, Danecek, Petr, Coorens, Tim, Prigmore, Elena, Short, Patrick, Gallone, Giuseppe, McRae, Jeremy, Carmichael, Jenny, Barnicoat, Angela, Firth, Helen, O’Brien, Patrick, Rahbari, Raheleh, Hurles, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117138/
https://www.ncbi.nlm.nih.gov/pubmed/35545669
http://dx.doi.org/10.1038/s41586-022-04712-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117138/
https://www.ncbi.nlm.nih.gov/pubmed/35545669
http://dx.doi.org/10.1038/s41586-022-04712-2

Ejemplares similares