Nonlinear mechanics of human mitotic chromosomes

In preparation for mitotic cell division, the nuclear DNA of human cells is compacted into individualized, X-shaped chromosomes(1). This metamorphosis is driven mainly by the combined action of condensins and topoisomerase IIα (TOP2A)(2,3), and has been observed using microscopy for over a century....

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Detalles Bibliográficos
Autores principales: Meijering, Anna E. C., Sarlós, Kata, Nielsen, Christian F., Witt, Hannes, Harju, Janni, Kerklingh, Emma, Haasnoot, Guus H., Bizard, Anna H., Heller, Iddo, Broedersz, Chase P., Liu, Ying, Peterman, Erwin J. G., Hickson, Ian D., Wuite, Gijs J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117150/
https://www.ncbi.nlm.nih.gov/pubmed/35508652
http://dx.doi.org/10.1038/s41586-022-04666-5

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