HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

The biological role of RNA-binding proteins in the secretory pathway is not well established. Here, we describe that human HDLBP/Vigilin directly interacts with more than 80% of ER-localized mRNAs. PAR-CLIP analysis reveals that these transcripts represent high affinity HDLBP substrates and are spec...

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Detalles Bibliográficos
Autores principales: Zinnall, Ulrike, Milek, Miha, Minia, Igor, Vieira-Vieira, Carlos H., Müller, Simon, Mastrobuoni, Guido, Hazapis, Orsalia-Georgia, Del Giudice, Simone, Schwefel, David, Bley, Nadine, Voigt, Franka, Chao, Jeffrey A., Kempa, Stefan, Hüttelmaier, Stefan, Selbach, Matthias, Landthaler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117268/
https://www.ncbi.nlm.nih.gov/pubmed/35585045
http://dx.doi.org/10.1038/s41467-022-30322-7

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