Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation

Bacterial binding to host receptors underlies both commensalism and pathogenesis. Many streptococci adhere to protein-attached carbohydrates expressed on cell surfaces using Siglec-like binding regions (SLBRs). The precise glycan repertoire recognized may dictate whether the organism is a strict com...

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Detalles Bibliográficos
Autores principales: Bensing, Barbara A., Stubbs, Haley E., Agarwal, Rupesh, Yamakawa, Izumi, Luong, Kelvin, Solakyildirim, Kemal, Yu, Hai, Hadadianpour, Azadeh, Castro, Manuel A., Fialkowski, Kevin P., Morrison, KeAndreya M., Wawrzak, Zdzislaw, Chen, Xi, Lebrilla, Carlito B., Baudry, Jerome, Smith, Jeremy C., Sullam, Paul M., Iverson, T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117288/
https://www.ncbi.nlm.nih.gov/pubmed/35585145
http://dx.doi.org/10.1038/s41467-022-30509-y

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