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Characterization of a novel + 70 Da modification in rhGM-CSF expressed in E. coli using chemical assays in combination with mass spectrometry

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine and a white blood cell growth factor that has found usage as a therapeutic protein. During analysis of different fermentation batches of GM-CSF recombinantly expressed in E. coli, a covalent modification was identified on the pr...

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Detalles Bibliográficos
Autores principales:	Sandberg, Magdalena Widgren, Bunkenborg, Jakob, Thyssen, Stine, Villadsen, Martin, Kofoed, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Vienna 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117350/ https://www.ncbi.nlm.nih.gov/pubmed/34453584 http://dx.doi.org/10.1007/s00726-021-03004-9

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