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Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment

Hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine] is a derivative of lysine that is formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a single site in one cellular protein defines hypusine synthesis as one of the most specific post-translational modifications...

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Detalles Bibliográficos
Autores principales: Park, Myung Hee, Kar, Rajesh Kumar, Banka, Siddharth, Ziegler, Alban, Chung, Wendy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117371/
https://www.ncbi.nlm.nih.gov/pubmed/34273022
http://dx.doi.org/10.1007/s00726-021-03023-6