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Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020
BACKGROUND: Viridans group streptococci (VGS) are typically part of the commensal flora but can also cause severe invasive diseases such as infective endocarditis. There are limited data available showing antibiotic susceptibility over time for VGS. OBJECTIVES: To evaluate antibiotic susceptibility...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117386/ https://www.ncbi.nlm.nih.gov/pubmed/35599725 http://dx.doi.org/10.1093/jacamr/dlac049 |
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author | Singh, Nidhi Poggensee, Linda Huang, Yanqin Evans, Charlesnika T. Suda, Katie J. Bulman, Zackery P. |
author_facet | Singh, Nidhi Poggensee, Linda Huang, Yanqin Evans, Charlesnika T. Suda, Katie J. Bulman, Zackery P. |
author_sort | Singh, Nidhi |
collection | PubMed |
description | BACKGROUND: Viridans group streptococci (VGS) are typically part of the commensal flora but can also cause severe invasive diseases such as infective endocarditis. There are limited data available showing antibiotic susceptibility over time for VGS. OBJECTIVES: To evaluate antibiotic susceptibility trends in VGS over time. METHODS: In vitro susceptibility patterns for 33 antibiotics were examined for Streptococcus mitis, Streptococcus oralis, and non-speciated VGS isolates from patients in Veterans Affairs (VA) Medical Centers in the United States between 2010 and 2020. Susceptibility determinations were made by the individual clinical microbiology laboratories and data were retrospectively collected from the VA Corporate Data Warehouse. Susceptibility trends were analysed using Poisson regression. RESULTS: A total of 14 981 VGS isolates were included of which 19.5%, 0.7% and 79.8% were S. mitis, S. oralis and non-speciated VGS isolates, respectively. Cumulative susceptibility rates across all years were similar between species for ceftriaxone (range: 96.0% to 100%), clindamycin (81.3% to 84.5%), and vancomycin (99.7% to 100%). For penicillin, susceptibility rates were 71.0%, 80.9% and 86.3% for S. mitis, S. oralis and non-speciated isolates, respectively. From 2010 to 2020, susceptibility of non-speciated VGS isolates decreased for erythromycin (P = 0.0674), penicillin (P = 0.0835), and tetracycline (P = 0.0994); though the decrease was only significant for clindamycin (P = 0.0033). For S. mitis, a significant susceptibility rate decrease was observed for erythromycin (P = 0.0112). CONCLUSIONS: Susceptibility rates for some clinically relevant antibiotics declined between 2010 and 2020. This worrisome trend highlights the need to improve antimicrobial stewardship efforts to limit unnecessary antibiotic use and preserve empirical treatment options. |
format | Online Article Text |
id | pubmed-9117386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91173862022-05-19 Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 Singh, Nidhi Poggensee, Linda Huang, Yanqin Evans, Charlesnika T. Suda, Katie J. Bulman, Zackery P. JAC Antimicrob Resist Original Article BACKGROUND: Viridans group streptococci (VGS) are typically part of the commensal flora but can also cause severe invasive diseases such as infective endocarditis. There are limited data available showing antibiotic susceptibility over time for VGS. OBJECTIVES: To evaluate antibiotic susceptibility trends in VGS over time. METHODS: In vitro susceptibility patterns for 33 antibiotics were examined for Streptococcus mitis, Streptococcus oralis, and non-speciated VGS isolates from patients in Veterans Affairs (VA) Medical Centers in the United States between 2010 and 2020. Susceptibility determinations were made by the individual clinical microbiology laboratories and data were retrospectively collected from the VA Corporate Data Warehouse. Susceptibility trends were analysed using Poisson regression. RESULTS: A total of 14 981 VGS isolates were included of which 19.5%, 0.7% and 79.8% were S. mitis, S. oralis and non-speciated VGS isolates, respectively. Cumulative susceptibility rates across all years were similar between species for ceftriaxone (range: 96.0% to 100%), clindamycin (81.3% to 84.5%), and vancomycin (99.7% to 100%). For penicillin, susceptibility rates were 71.0%, 80.9% and 86.3% for S. mitis, S. oralis and non-speciated isolates, respectively. From 2010 to 2020, susceptibility of non-speciated VGS isolates decreased for erythromycin (P = 0.0674), penicillin (P = 0.0835), and tetracycline (P = 0.0994); though the decrease was only significant for clindamycin (P = 0.0033). For S. mitis, a significant susceptibility rate decrease was observed for erythromycin (P = 0.0112). CONCLUSIONS: Susceptibility rates for some clinically relevant antibiotics declined between 2010 and 2020. This worrisome trend highlights the need to improve antimicrobial stewardship efforts to limit unnecessary antibiotic use and preserve empirical treatment options. Oxford University Press 2022-05-19 /pmc/articles/PMC9117386/ /pubmed/35599725 http://dx.doi.org/10.1093/jacamr/dlac049 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Singh, Nidhi Poggensee, Linda Huang, Yanqin Evans, Charlesnika T. Suda, Katie J. Bulman, Zackery P. Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 |
title | Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 |
title_full | Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 |
title_fullStr | Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 |
title_full_unstemmed | Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 |
title_short | Antibiotic susceptibility patterns of viridans group streptococci isolates in the United States from 2010 to 2020 |
title_sort | antibiotic susceptibility patterns of viridans group streptococci isolates in the united states from 2010 to 2020 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117386/ https://www.ncbi.nlm.nih.gov/pubmed/35599725 http://dx.doi.org/10.1093/jacamr/dlac049 |
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