CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is characterized by clonal expansion of NK cells where the underlying genetic mechanisms are incompletely understood. Here, we report somatic mutations in the chemokine gene CCL22 as the hallmark of a distinct subset of CLPD-NK....

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Detalles Bibliográficos
Autores principales: Baer, Constance, Kimura, Shunsuke, Rana, Mitra S., Kleist, Andrew B., Flerlage, Tim, Feith, David J., Chockley, Peter, Walter, Wencke, Meggendorfer, Manja, Olson, Thomas L., Cheon, HeeJin, Olson, Kristine C., Ratan, Aakrosh, Mueller, Martha-Lena, Foran, James M., Janke, Laura J., Qu, Chunxu, Porter, Shaina N., Pruett-Miller, Shondra M., Kalathur, Ravi C., Haferlach, Claudia, Kern, Wolfgang, Paietta, Elisabeth, Thomas, Paul G., Babu, M. Madan, Loughran, Thomas P., Iacobucci, Ilaria, Haferlach, Torsten, Mullighan, Charles G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117519/
https://www.ncbi.nlm.nih.gov/pubmed/35513723
http://dx.doi.org/10.1038/s41588-022-01059-2

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