Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

Glycyrrhetinic acid (GA) is a natural product of licorice with mitochondria targeting properties and shows broad anticancer activities, but its targets and underlying mechanisms remain elusive. Here, we identified the mitochondrial enzyme serine hydroxymethyltransferase 2 (SHMT2) as a target of GA b...

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Detalles Bibliográficos
Autores principales: Jin, Xiuxiu, Li, Li, Peng, Qinlu, Gan, Chunmei, Gao, Li, He, Siyu, Tan, Shuangyan, Pu, Wenchen, Liu, Yu, Gong, Yanqiu, Yao, Yuqin, Wang, Gang, Liu, Xiaohui, Gong, Meng, Lei, Peng, Zhang, Huiyuan, Qi, Shiqian, Xu, Heng, Hu, Hongbo, Dong, Biao, Peng, Yong, Su, Dan, Dai, Lunzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117551/
https://www.ncbi.nlm.nih.gov/pubmed/35602963
http://dx.doi.org/10.1016/j.isci.2022.104349

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