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The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice

BACKGROUND & AIMS: A hybrid allele that originated from homologous recombination between CEL and its pseudogene (CELP), CEL-HYB1 increases the risk of chronic pancreatitis (CP). Although suggested to cause digestive enzyme misfolding, definitive in vivo evidence for this postulate has been lacki...

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Detalles Bibliográficos
Autores principales:	Mao, Xiao-Tong, Zou, Wen-Bin, Cao, Yu, Wang, Yuan-Chen, Deng, Shun-Jiang, Cooper, David N., Férec, Claude, Li, Zhao-Shen, Chen, Jian-Min, Liao, Zhuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117557/ https://www.ncbi.nlm.nih.gov/pubmed/35398595 http://dx.doi.org/10.1016/j.jcmgh.2022.03.013

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