Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas

Oncoprotein SS18-SSX is a hallmark of synovial sarcomas. However, as a part of the SS18-SSX fusion protein, SS18’s function remains unclear. Here, we depict the structures of both human SS18/BRG1 and yeast SNF11/SNF2 subcomplexes. Both subcomplexes assemble into heterodimers that share a similar con...

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Detalles Bibliográficos
Autores principales: Cheng, Yanli, Shen, Zhongtian, Gao, Yaqi, Chen, Feilong, Xu, Huisha, Mo, Qinling, Chu, Xinlei, Peng, Chang-liang, McKenzie, Takese T., Palacios, Bridgitte E., Hu, Jian, Zhou, Hao, Long, Jiafu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117659/
https://www.ncbi.nlm.nih.gov/pubmed/35585082
http://dx.doi.org/10.1038/s41467-022-30447-9

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