Delineating the conformational landscape and intrinsic properties of the angiotensin II type 2 receptor using a computational study

As a key regulator for the renin-angiotensin system, a class A G protein-coupled receptor (GPCR), AngII type 2 receptor (AT(2)R), plays a pivotal role in the homeostasis of the cardiovascular system. Compared with other GPCRs, AT(2)R has a unique antagonist-bound conformation and its mechanism is st...

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Detalles Bibliográficos
Autores principales: Cong, Xiaoliang, Zhang, Xiaogang, Liang, Xin, He, Xinheng, Tang, Yehua, Zheng, Xing, Lu, Shaoyong, Zhang, Jiayou, Chen, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117689/
https://www.ncbi.nlm.nih.gov/pubmed/35615027
http://dx.doi.org/10.1016/j.csbj.2022.05.012

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