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Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration

For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis wer...

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Autores principales: Habibi, Mohammad Mehdi, Ghasemi, Jahan B., Badiei, Alireza, Norouzi, Parviz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117690/
https://www.ncbi.nlm.nih.gov/pubmed/35585173
http://dx.doi.org/10.1038/s41598-022-12506-9
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author Habibi, Mohammad Mehdi
Ghasemi, Jahan B.
Badiei, Alireza
Norouzi, Parviz
author_facet Habibi, Mohammad Mehdi
Ghasemi, Jahan B.
Badiei, Alireza
Norouzi, Parviz
author_sort Habibi, Mohammad Mehdi
collection PubMed
description For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis were used in this method. CMK-5 nanostructures were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and Raman spectroscopy. Variables such as accumulation time and pH for the proposed sensor were optimized before quantitative analysis. To train the proposed sensor, standard mixtures of morphine (MOR), and methadone (MET) were prepared in the established linear ranges of the analyzes. The results obtained from training samples were used for PLS modeling. The efficiency of the model was determined using test and real matrix samples. The root mean square error of prediction and the squared correlation coefficients (R(2)(p)) for MET and MOR were estimated to be 0.00772 and 0.00892 and 0.948 to 0.990, respectively. The recoveries in urine samples were reported to be 97.0 and 105.6% for both MOR and MET, respectively.
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spelling pubmed-91176902022-05-20 Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration Habibi, Mohammad Mehdi Ghasemi, Jahan B. Badiei, Alireza Norouzi, Parviz Sci Rep Article For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis were used in this method. CMK-5 nanostructures were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and Raman spectroscopy. Variables such as accumulation time and pH for the proposed sensor were optimized before quantitative analysis. To train the proposed sensor, standard mixtures of morphine (MOR), and methadone (MET) were prepared in the established linear ranges of the analyzes. The results obtained from training samples were used for PLS modeling. The efficiency of the model was determined using test and real matrix samples. The root mean square error of prediction and the squared correlation coefficients (R(2)(p)) for MET and MOR were estimated to be 0.00772 and 0.00892 and 0.948 to 0.990, respectively. The recoveries in urine samples were reported to be 97.0 and 105.6% for both MOR and MET, respectively. Nature Publishing Group UK 2022-05-18 /pmc/articles/PMC9117690/ /pubmed/35585173 http://dx.doi.org/10.1038/s41598-022-12506-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Habibi, Mohammad Mehdi
Ghasemi, Jahan B.
Badiei, Alireza
Norouzi, Parviz
Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
title Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
title_full Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
title_fullStr Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
title_full_unstemmed Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
title_short Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
title_sort simultaneous electrochemical determination of morphine and methadone by using cmk-5 mesoporous carbon and multivariate calibration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117690/
https://www.ncbi.nlm.nih.gov/pubmed/35585173
http://dx.doi.org/10.1038/s41598-022-12506-9
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