Cargando…

Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature

Nowadays, short stature (SS) in childhood is a common condition encountered by pediatricians, with an increase in not just a few families. Various studies related to the variations in key metabolites and their biological mechanisms that lead to SS have increased our understanding of the pathophysiol...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Guoyou, Wang, Jinming, Jing, Yisi, Li, Chunxiang, Zhang, Wenyue, Yang, Shuang, Song, Ye, Wang, Xin, Liu, Jincheng, Yu, Dejun, Xu, Zhichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117746/
https://www.ncbi.nlm.nih.gov/pubmed/35600884
http://dx.doi.org/10.3389/fphar.2022.818952
_version_ 1784710378659250176
author Chen, Guoyou
Wang, Jinming
Jing, Yisi
Li, Chunxiang
Zhang, Wenyue
Yang, Shuang
Song, Ye
Wang, Xin
Liu, Jincheng
Yu, Dejun
Xu, Zhichun
author_facet Chen, Guoyou
Wang, Jinming
Jing, Yisi
Li, Chunxiang
Zhang, Wenyue
Yang, Shuang
Song, Ye
Wang, Xin
Liu, Jincheng
Yu, Dejun
Xu, Zhichun
author_sort Chen, Guoyou
collection PubMed
description Nowadays, short stature (SS) in childhood is a common condition encountered by pediatricians, with an increase in not just a few families. Various studies related to the variations in key metabolites and their biological mechanisms that lead to SS have increased our understanding of the pathophysiology of the disease. However, little is known about the role of metabolite variation in different types of childhood SS that influence these biological processes and whether the understanding of the key metabolites from different types of childhood SS would predict the disease progression better. We performed a systematic investigation using the metabonomics method and studied the correlation between the three groups, namely, the control, idiopathic short stature (ISS), and short stature due to growth hormone deficiency (GHD). We observed that three pathways (viz., purine metabolism, sphingolipid signaling pathway, and sphingolipid metabolism) were significantly enriched in childhood SS. Moreover, we reported that two short peptides (Thr Val Leu Thr Ser and Trp Ile Lys) might play a significant role in childhood SS. Various metabolites in different pathways including 9,10-DiHOME, 12-HETE, 12(13)-EpOME, arachidonic acid methyl ester, glycerophospho-N-arachidonoyl ethanolamine, curvulinic acid (2-acetyl-3,5-dihydroxyphenyl acetic acid), nonanoic acid, and N'-(2,4-dimethylphenyl)-N-methylformamidine in human serum were compared between 60 children diagnosed with SS and 30 normal-height children. More investigations in this area may provide insights and enhance the personalized treatment approaches in clinical practice for SS by elucidating pathophysiology mechanisms of experimental verification.
format Online
Article
Text
id pubmed-9117746
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91177462022-05-20 Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature Chen, Guoyou Wang, Jinming Jing, Yisi Li, Chunxiang Zhang, Wenyue Yang, Shuang Song, Ye Wang, Xin Liu, Jincheng Yu, Dejun Xu, Zhichun Front Pharmacol Pharmacology Nowadays, short stature (SS) in childhood is a common condition encountered by pediatricians, with an increase in not just a few families. Various studies related to the variations in key metabolites and their biological mechanisms that lead to SS have increased our understanding of the pathophysiology of the disease. However, little is known about the role of metabolite variation in different types of childhood SS that influence these biological processes and whether the understanding of the key metabolites from different types of childhood SS would predict the disease progression better. We performed a systematic investigation using the metabonomics method and studied the correlation between the three groups, namely, the control, idiopathic short stature (ISS), and short stature due to growth hormone deficiency (GHD). We observed that three pathways (viz., purine metabolism, sphingolipid signaling pathway, and sphingolipid metabolism) were significantly enriched in childhood SS. Moreover, we reported that two short peptides (Thr Val Leu Thr Ser and Trp Ile Lys) might play a significant role in childhood SS. Various metabolites in different pathways including 9,10-DiHOME, 12-HETE, 12(13)-EpOME, arachidonic acid methyl ester, glycerophospho-N-arachidonoyl ethanolamine, curvulinic acid (2-acetyl-3,5-dihydroxyphenyl acetic acid), nonanoic acid, and N'-(2,4-dimethylphenyl)-N-methylformamidine in human serum were compared between 60 children diagnosed with SS and 30 normal-height children. More investigations in this area may provide insights and enhance the personalized treatment approaches in clinical practice for SS by elucidating pathophysiology mechanisms of experimental verification. Frontiers Media S.A. 2022-05-05 /pmc/articles/PMC9117746/ /pubmed/35600884 http://dx.doi.org/10.3389/fphar.2022.818952 Text en Copyright © 2022 Chen, Wang, Jing, Li, Zhang, Yang, Song, Wang, Liu, Yu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Guoyou
Wang, Jinming
Jing, Yisi
Li, Chunxiang
Zhang, Wenyue
Yang, Shuang
Song, Ye
Wang, Xin
Liu, Jincheng
Yu, Dejun
Xu, Zhichun
Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature
title Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature
title_full Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature
title_fullStr Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature
title_full_unstemmed Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature
title_short Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature
title_sort serum metabonomics reveals key metabolites in different types of childhood short stature
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117746/
https://www.ncbi.nlm.nih.gov/pubmed/35600884
http://dx.doi.org/10.3389/fphar.2022.818952
work_keys_str_mv AT chenguoyou serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT wangjinming serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT jingyisi serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT lichunxiang serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT zhangwenyue serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT yangshuang serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT songye serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT wangxin serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT liujincheng serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT yudejun serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature
AT xuzhichun serummetabonomicsrevealskeymetabolitesindifferenttypesofchildhoodshortstature