Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma

Immune checkpoint inhibitors like programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are biological agents that help in boosting the immune system of the body to fight against cancer cells. These checkpoint inhibitors are now being approved by the Food and Drug A...

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Detalles Bibliográficos
Autores principales: Ehsanullah, Syed, Muhammad, Azharuddin, Hasan, Syed, Richart, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117826/
https://www.ncbi.nlm.nih.gov/pubmed/35600068
http://dx.doi.org/10.7759/cureus.25067
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author Ehsanullah, Syed
Muhammad, Azharuddin
Hasan, Syed
Richart, John M
author_facet Ehsanullah, Syed
Muhammad, Azharuddin
Hasan, Syed
Richart, John M
author_sort Ehsanullah, Syed
collection PubMed
description Immune checkpoint inhibitors like programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are biological agents that help in boosting the immune system of the body to fight against cancer cells. These checkpoint inhibitors are now being approved by the Food and Drug Administration (FDA) to treat various malignancies due to remarkable response. Here, we present a rare immune-related adverse event in a 77-year-old female with metastatic melanoma treated with ipilimumab and nivolumab, later presented with auto-splenectomy.
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spelling pubmed-91178262022-05-20 Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma Ehsanullah, Syed Muhammad, Azharuddin Hasan, Syed Richart, John M Cureus Internal Medicine Immune checkpoint inhibitors like programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are biological agents that help in boosting the immune system of the body to fight against cancer cells. These checkpoint inhibitors are now being approved by the Food and Drug Administration (FDA) to treat various malignancies due to remarkable response. Here, we present a rare immune-related adverse event in a 77-year-old female with metastatic melanoma treated with ipilimumab and nivolumab, later presented with auto-splenectomy. Cureus 2022-05-17 /pmc/articles/PMC9117826/ /pubmed/35600068 http://dx.doi.org/10.7759/cureus.25067 Text en Copyright © 2022, Ehsanullah et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ehsanullah, Syed
Muhammad, Azharuddin
Hasan, Syed
Richart, John M
Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma
title Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma
title_full Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma
title_fullStr Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma
title_full_unstemmed Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma
title_short Immunotherapy-Induced Auto-Splenectomy in a Patient of Malignant Melanoma
title_sort immunotherapy-induced auto-splenectomy in a patient of malignant melanoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117826/
https://www.ncbi.nlm.nih.gov/pubmed/35600068
http://dx.doi.org/10.7759/cureus.25067
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AT hasansyed immunotherapyinducedautosplenectomyinapatientofmalignantmelanoma
AT richartjohnm immunotherapyinducedautosplenectomyinapatientofmalignantmelanoma

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