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NR5A2/LRH-1 regulates the PTGS2-PGE(2)-PTGER1 pathway contributing to pancreatic islet survival and function

LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling revealed that the expression of PTGS2/COX2 is increased by BL...

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Detalles Bibliográficos
Autores principales:	Martin Vázquez, Eugenia, Cobo-Vuilleumier, Nadia, Araujo Legido, Raquel, Marín-Cañas, Sandra, Nola, Emanuele, Dorronsoro, Akaitz, López Bermudo, Lucia, Crespo, Alejandra, Romero-Zerbo, Silvana Y., García-Fernández, Maria, Martin Montalvo, Alejandro, Rojas, Anabel, Comaills, Valentine, Bérmudez-Silva, Francisco J., Gannon, Maureen, Martin, Franz, Eizirik, Decio, Lorenzo, Petra I., Gauthier, Benoit R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117883/ https://www.ncbi.nlm.nih.gov/pubmed/35602948 http://dx.doi.org/10.1016/j.isci.2022.104345

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