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Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3

Neuregulins (NRGs) are EGF-like ligands associated with cognitive disorders. Unprocessed proNRG3 is cleaved by BACE1 to generate the mature membrane-bound NRG3 ligand, but the subcellular site of proNRG3 cleavage, mechanisms underlying its transport into axons, and presynaptic accumulation remain un...

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Detalles Bibliográficos
Autores principales:	Ahmad, Tanveer, Vullhorst, Detlef, Chaudhuri, Rituparna, Guardia, Carlos M., Chaudhary, Nisha, Karavanova, Irina, Bonifacino, Juan S., Buonanno, Andres
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118086/ https://www.ncbi.nlm.nih.gov/pubmed/35579602 http://dx.doi.org/10.1083/jcb.202110167

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