On-line Coupling of Aptamer Affinity Solid-Phase Extraction and Immobilized Enzyme Microreactor Capillary Electrophoresis-Mass Spectrometry for the Sensitive Targeted Bottom-Up Analysis of Protein Biomarkers

[Image: see text] In this paper, we present a fully integrated valve-free method for the sensitive targeted bottom-up analysis of proteins through on-line aptamer affinity solid-phase extraction and immobilized enzyme microreactor capillary electrophoresis-mass spectrometry (AA-SPE-IMER-CE-MS). The...

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Detalles Bibliográficos
Autores principales: Salim, Hiba, Pero-Gascon, Roger, Giménez, Estela, Benavente, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118193/
https://www.ncbi.nlm.nih.gov/pubmed/35500203
http://dx.doi.org/10.1021/acs.analchem.1c03800

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