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Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria

[Image: see text] Ag(3)PO(4) nanostructures (APNs) containing silver (Ag metal; of the noble metal families) have the potential to exhibit enzyme-mimetic activity. A nanostructure shape, including its surface facets, can improve the bioactivity of enzyme mimicry, yet the molecular mechanisms remain...

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Autores principales: Singh, Kamini, Gujju, Rajesh, Bandaru, Sateesh, Misra, Sunil, Babu, Katragadda Suresh, Puvvada, Nagaprasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118378/
https://www.ncbi.nlm.nih.gov/pubmed/35601325
http://dx.doi.org/10.1021/acsomega.2c00864
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author Singh, Kamini
Gujju, Rajesh
Bandaru, Sateesh
Misra, Sunil
Babu, Katragadda Suresh
Puvvada, Nagaprasad
author_facet Singh, Kamini
Gujju, Rajesh
Bandaru, Sateesh
Misra, Sunil
Babu, Katragadda Suresh
Puvvada, Nagaprasad
author_sort Singh, Kamini
collection PubMed
description [Image: see text] Ag(3)PO(4) nanostructures (APNs) containing silver (Ag metal; of the noble metal families) have the potential to exhibit enzyme-mimetic activity. A nanostructure shape, including its surface facets, can improve the bioactivity of enzyme mimicry, yet the molecular mechanisms remain unclear. Herein, we report facet-dependent peroxidase and oxidase-like activity of APNs with both antibacterial and biofilm degrading properties through the generation of reactive oxygen species. Cubic APNs had superior antibacterial effects than rhombic dodecahedral shapes when inhibiting Gram-positive and Gram-negative bacterial pathogen proliferation and biofilm degradation. A similar performance was observed for rhombic dodecahedral shapes, being greater than tetrahedral-shaped APNs. The extent of enzyme-mimetic activity is attributed to the facets {100} present in cubic APNs that led the peroxide radicals to inhibit the proliferation of bacteria and degrade biofilm. These facets were compared to rhombic dodecahedral APNs {110} and tetrahedral APNs {111}, respectively, to reveal a facet-dependent enhanced antibacterial activity, providing a plausible mechanism for shape-dependent APNs material enzyme-mimetic effects on bacteria. Thus, our research findings can provide a direction to optimize bactericidal materials using APNs in clinically relevant applications.
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spelling pubmed-91183782022-05-20 Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria Singh, Kamini Gujju, Rajesh Bandaru, Sateesh Misra, Sunil Babu, Katragadda Suresh Puvvada, Nagaprasad ACS Omega [Image: see text] Ag(3)PO(4) nanostructures (APNs) containing silver (Ag metal; of the noble metal families) have the potential to exhibit enzyme-mimetic activity. A nanostructure shape, including its surface facets, can improve the bioactivity of enzyme mimicry, yet the molecular mechanisms remain unclear. Herein, we report facet-dependent peroxidase and oxidase-like activity of APNs with both antibacterial and biofilm degrading properties through the generation of reactive oxygen species. Cubic APNs had superior antibacterial effects than rhombic dodecahedral shapes when inhibiting Gram-positive and Gram-negative bacterial pathogen proliferation and biofilm degradation. A similar performance was observed for rhombic dodecahedral shapes, being greater than tetrahedral-shaped APNs. The extent of enzyme-mimetic activity is attributed to the facets {100} present in cubic APNs that led the peroxide radicals to inhibit the proliferation of bacteria and degrade biofilm. These facets were compared to rhombic dodecahedral APNs {110} and tetrahedral APNs {111}, respectively, to reveal a facet-dependent enhanced antibacterial activity, providing a plausible mechanism for shape-dependent APNs material enzyme-mimetic effects on bacteria. Thus, our research findings can provide a direction to optimize bactericidal materials using APNs in clinically relevant applications. American Chemical Society 2022-05-02 /pmc/articles/PMC9118378/ /pubmed/35601325 http://dx.doi.org/10.1021/acsomega.2c00864 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Singh, Kamini
Gujju, Rajesh
Bandaru, Sateesh
Misra, Sunil
Babu, Katragadda Suresh
Puvvada, Nagaprasad
Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria
title Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria
title_full Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria
title_fullStr Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria
title_full_unstemmed Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria
title_short Facet-Dependent Bactericidal Activity of Ag(3)PO(4) Nanostructures against Gram-Positive/Negative Bacteria
title_sort facet-dependent bactericidal activity of ag(3)po(4) nanostructures against gram-positive/negative bacteria
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118378/
https://www.ncbi.nlm.nih.gov/pubmed/35601325
http://dx.doi.org/10.1021/acsomega.2c00864
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