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Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review
Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as obesity and diabetes mellitus, leading to increased mortality. Antipsychotics (APs), which are the mainstay in the tre...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118432/ https://www.ncbi.nlm.nih.gov/pubmed/35600753 http://dx.doi.org/10.1177/20451253221096525 |
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author | Singh, Raghunath Stogios, Nicolette Smith, Emily Lee, Jiwon Maksyutynsk, Kateryna Au, Emily Wright, David C. De Palma, Giada Graff-Guerrero, Ariel Gerretsen, Philip Müller, Daniel J. Remington, Gary Hahn, Margaret Agarwal, Sri Mahavir |
author_facet | Singh, Raghunath Stogios, Nicolette Smith, Emily Lee, Jiwon Maksyutynsk, Kateryna Au, Emily Wright, David C. De Palma, Giada Graff-Guerrero, Ariel Gerretsen, Philip Müller, Daniel J. Remington, Gary Hahn, Margaret Agarwal, Sri Mahavir |
author_sort | Singh, Raghunath |
collection | PubMed |
description | Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as obesity and diabetes mellitus, leading to increased mortality. Antipsychotics (APs), which are the mainstay in the treatment of SCZ, increase the risk of these metabolic perturbations. Despite extensive research, the mechanism underlying SCZ pathophysiology and associated metabolic comorbidities remains unclear. In recent years, gut microbiota (GMB) has been regarded as a ‘chamber of secrets’, particularly in the context of severe mental illnesses such as SCZ, depression, and bipolar disorder. In this scoping review, we aimed to investigate the underlying role of GMB in the pathophysiology of SCZ and metabolic alterations associated with APs. Furthermore, we also explored the therapeutic benefits of prebiotic and probiotic formulations in managing SCZ and AP-induced metabolic alterations. A systematic literature search yielded 46 studies from both preclinical and clinical settings that met inclusion criteria for qualitative synthesis. Preliminary evidence from preclinical and clinical studies indicates that GMB composition changes are associated with SCZ pathogenesis and AP-induced metabolic perturbations. Fecal microbiota transplantation from SCZ patients to mice has been shown to induce SCZ-like behavioral phenotypes, further supporting the plausible role of GMB in SCZ pathogenesis. This scoping review recapitulates the preclinical and clinical evidence suggesting the role of GMB in SCZ symptomatology and metabolic adverse effects associated with APs. Moreover, this scoping review also discusses the therapeutic potentials of prebiotic/probiotic formulations in improving SCZ symptoms and attenuating metabolic alterations related to APs. |
format | Online Article Text |
id | pubmed-9118432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91184322022-05-20 Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review Singh, Raghunath Stogios, Nicolette Smith, Emily Lee, Jiwon Maksyutynsk, Kateryna Au, Emily Wright, David C. De Palma, Giada Graff-Guerrero, Ariel Gerretsen, Philip Müller, Daniel J. Remington, Gary Hahn, Margaret Agarwal, Sri Mahavir Ther Adv Psychopharmacol Review Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as obesity and diabetes mellitus, leading to increased mortality. Antipsychotics (APs), which are the mainstay in the treatment of SCZ, increase the risk of these metabolic perturbations. Despite extensive research, the mechanism underlying SCZ pathophysiology and associated metabolic comorbidities remains unclear. In recent years, gut microbiota (GMB) has been regarded as a ‘chamber of secrets’, particularly in the context of severe mental illnesses such as SCZ, depression, and bipolar disorder. In this scoping review, we aimed to investigate the underlying role of GMB in the pathophysiology of SCZ and metabolic alterations associated with APs. Furthermore, we also explored the therapeutic benefits of prebiotic and probiotic formulations in managing SCZ and AP-induced metabolic alterations. A systematic literature search yielded 46 studies from both preclinical and clinical settings that met inclusion criteria for qualitative synthesis. Preliminary evidence from preclinical and clinical studies indicates that GMB composition changes are associated with SCZ pathogenesis and AP-induced metabolic perturbations. Fecal microbiota transplantation from SCZ patients to mice has been shown to induce SCZ-like behavioral phenotypes, further supporting the plausible role of GMB in SCZ pathogenesis. This scoping review recapitulates the preclinical and clinical evidence suggesting the role of GMB in SCZ symptomatology and metabolic adverse effects associated with APs. Moreover, this scoping review also discusses the therapeutic potentials of prebiotic/probiotic formulations in improving SCZ symptoms and attenuating metabolic alterations related to APs. SAGE Publications 2022-05-15 /pmc/articles/PMC9118432/ /pubmed/35600753 http://dx.doi.org/10.1177/20451253221096525 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Singh, Raghunath Stogios, Nicolette Smith, Emily Lee, Jiwon Maksyutynsk, Kateryna Au, Emily Wright, David C. De Palma, Giada Graff-Guerrero, Ariel Gerretsen, Philip Müller, Daniel J. Remington, Gary Hahn, Margaret Agarwal, Sri Mahavir Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
title | Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
title_full | Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
title_fullStr | Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
title_full_unstemmed | Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
title_short | Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
title_sort | gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118432/ https://www.ncbi.nlm.nih.gov/pubmed/35600753 http://dx.doi.org/10.1177/20451253221096525 |
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