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Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases

OBJECTIVES: Lysosomal acid lipase (LAL) is the key enzyme, which degrades neutral lipids at an acidic pH in lysosomes. The role of LAL in various cellular processes has mostly been studied in LAL-knockout mice, which share phenotypical characteristics with humans suffering from LAL deficiency. In vi...

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Detalles Bibliográficos
Autores principales:	Bradić, Ivan, Kuentzel, Katharina B., Honeder, Sophie, Grabner, Gernot F., Vujić, Nemanja, Zimmermann, Robert, Birner-Gruenberger, Ruth, Kratky, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118473/ https://www.ncbi.nlm.nih.gov/pubmed/35504532 http://dx.doi.org/10.1016/j.molmet.2022.101510

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