Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia

BACKGROUND: CD26 is expressed in all chronic myeloid leukemia (CML) patients. This study investigated the role of CD26(+) LSCs in diagnosis and follow up of CML patients. METHOD: Flow cytometry was performed to evaluate CD26(+) LSC in peripheral blood (PB) in CML patients. BCR-ABL1 transcript level...

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Autores principales: Ebian, Huda F, Abdelnabi, AL-Shabrawy M., Abdelazem, Abdallah S., Khamis, Tarek, Fawzy, Hebatallah M., Hussein, Samia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118510/
https://www.ncbi.nlm.nih.gov/pubmed/35602932
http://dx.doi.org/10.1016/j.lrr.2022.100321
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author Ebian, Huda F
Abdelnabi, AL-Shabrawy M.
Abdelazem, Abdallah S.
Khamis, Tarek
Fawzy, Hebatallah M.
Hussein, Samia
author_facet Ebian, Huda F
Abdelnabi, AL-Shabrawy M.
Abdelazem, Abdallah S.
Khamis, Tarek
Fawzy, Hebatallah M.
Hussein, Samia
author_sort Ebian, Huda F
collection PubMed
description BACKGROUND: CD26 is expressed in all chronic myeloid leukemia (CML) patients. This study investigated the role of CD26(+) LSCs in diagnosis and follow up of CML patients. METHOD: Flow cytometry was performed to evaluate CD26(+) LSC in peripheral blood (PB) in CML patients. BCR-ABL1 transcript level measurement was performed using standard qRT-PCR technique. RESULTS: CD26(+) LSCs were significantly correlated with BCR-ABL1 transcript level at diagnosis and after three months of treatment. CD26+ LSCs also were significantly associated with the risk score after 12 months of treatment. CONCLUSION: CD26+ LSCs can be a useful marker in diagnosis and follow up of patients with CML.
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spelling pubmed-91185102022-05-20 Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia Ebian, Huda F Abdelnabi, AL-Shabrawy M. Abdelazem, Abdallah S. Khamis, Tarek Fawzy, Hebatallah M. Hussein, Samia Leuk Res Rep Article BACKGROUND: CD26 is expressed in all chronic myeloid leukemia (CML) patients. This study investigated the role of CD26(+) LSCs in diagnosis and follow up of CML patients. METHOD: Flow cytometry was performed to evaluate CD26(+) LSC in peripheral blood (PB) in CML patients. BCR-ABL1 transcript level measurement was performed using standard qRT-PCR technique. RESULTS: CD26(+) LSCs were significantly correlated with BCR-ABL1 transcript level at diagnosis and after three months of treatment. CD26+ LSCs also were significantly associated with the risk score after 12 months of treatment. CONCLUSION: CD26+ LSCs can be a useful marker in diagnosis and follow up of patients with CML. Elsevier 2022-05-09 /pmc/articles/PMC9118510/ /pubmed/35602932 http://dx.doi.org/10.1016/j.lrr.2022.100321 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ebian, Huda F
Abdelnabi, AL-Shabrawy M.
Abdelazem, Abdallah S.
Khamis, Tarek
Fawzy, Hebatallah M.
Hussein, Samia
Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
title Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
title_full Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
title_fullStr Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
title_full_unstemmed Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
title_short Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
title_sort peripheral blood cd26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118510/
https://www.ncbi.nlm.nih.gov/pubmed/35602932
http://dx.doi.org/10.1016/j.lrr.2022.100321
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