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Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review

INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma characterized by weak or absent expression of conventional B cell markers and strong expression of plasma cell markers. Very few cases of PBL of the colon have been reported in HIV negative p...

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Autores principales: Pant, Ved Prakash, Dallakoti, Nishanta, KC, Priyanka, Mishra, Akshat, Pokharel, Sandip, Adhikari, Purbesh, Dulal, Soniya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118518/
https://www.ncbi.nlm.nih.gov/pubmed/35600199
http://dx.doi.org/10.1016/j.amsu.2022.103750
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author Pant, Ved Prakash
Dallakoti, Nishanta
KC, Priyanka
Mishra, Akshat
Pokharel, Sandip
Adhikari, Purbesh
Dulal, Soniya
author_facet Pant, Ved Prakash
Dallakoti, Nishanta
KC, Priyanka
Mishra, Akshat
Pokharel, Sandip
Adhikari, Purbesh
Dulal, Soniya
author_sort Pant, Ved Prakash
collection PubMed
description INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma characterized by weak or absent expression of conventional B cell markers and strong expression of plasma cell markers. Very few cases of PBL of the colon have been reported in HIV negative patients. CASE PRESENTATION: A 57 years female with HIV negative serology, a known case of hypertension under medication presented with right lower abdominal pain associated with vomiting and significant weight loss. On abdominal examination, soft, tender, and globular lump was palpable. Contrast enhanced computed tomography of abdomen and pelvis revealed asymmetrical enhancing mass like wall thickening involving ileocaecal region, caecum, and ascending colon, which on colonoscopy was found to be ulceroproliferative in nature. Open right hemicolectomy was performed and postoperative histopathology and immunohistochemistry results confirmed plasmablastic lymphoma as the final diagnosis. She was treated with nine cycles of chemotherapy. CLINICAL DISCUSSION: Although PBL is commonly found in the oral cavity, and HIV positive patients, it can rarely occur in extra-oral sites, and HIV negative patients. Due to its rarity, no optimal therapeutic approach has yet been defined for the treatment of PBL. It has a poor prognosis, and the overall survival rate has been correlated with international prognostic index score and achievement of complete remission. CONCLUSION: As plasmablastic lymphoma is rare and highly aggressive, its delayed diagnosis will lead to poor outcome. Thus, awareness about its clinical presentation, histopathological features, and immunophenotype is essential.
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spelling pubmed-91185182022-05-20 Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review Pant, Ved Prakash Dallakoti, Nishanta KC, Priyanka Mishra, Akshat Pokharel, Sandip Adhikari, Purbesh Dulal, Soniya Ann Med Surg (Lond) Case Report INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma characterized by weak or absent expression of conventional B cell markers and strong expression of plasma cell markers. Very few cases of PBL of the colon have been reported in HIV negative patients. CASE PRESENTATION: A 57 years female with HIV negative serology, a known case of hypertension under medication presented with right lower abdominal pain associated with vomiting and significant weight loss. On abdominal examination, soft, tender, and globular lump was palpable. Contrast enhanced computed tomography of abdomen and pelvis revealed asymmetrical enhancing mass like wall thickening involving ileocaecal region, caecum, and ascending colon, which on colonoscopy was found to be ulceroproliferative in nature. Open right hemicolectomy was performed and postoperative histopathology and immunohistochemistry results confirmed plasmablastic lymphoma as the final diagnosis. She was treated with nine cycles of chemotherapy. CLINICAL DISCUSSION: Although PBL is commonly found in the oral cavity, and HIV positive patients, it can rarely occur in extra-oral sites, and HIV negative patients. Due to its rarity, no optimal therapeutic approach has yet been defined for the treatment of PBL. It has a poor prognosis, and the overall survival rate has been correlated with international prognostic index score and achievement of complete remission. CONCLUSION: As plasmablastic lymphoma is rare and highly aggressive, its delayed diagnosis will lead to poor outcome. Thus, awareness about its clinical presentation, histopathological features, and immunophenotype is essential. Elsevier 2022-05-11 /pmc/articles/PMC9118518/ /pubmed/35600199 http://dx.doi.org/10.1016/j.amsu.2022.103750 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Pant, Ved Prakash
Dallakoti, Nishanta
KC, Priyanka
Mishra, Akshat
Pokharel, Sandip
Adhikari, Purbesh
Dulal, Soniya
Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review
title Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review
title_full Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review
title_fullStr Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review
title_full_unstemmed Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review
title_short Plasmablastic lymphoma of the colon in HIV negative patient; a case report with literature review
title_sort plasmablastic lymphoma of the colon in hiv negative patient; a case report with literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118518/
https://www.ncbi.nlm.nih.gov/pubmed/35600199
http://dx.doi.org/10.1016/j.amsu.2022.103750
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