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PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
[Image: see text] Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother–son dyads) in an urban community (East Chicago, Indiana) were analyzed for 74 sulfated metabolites of polychlorin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118556/ https://www.ncbi.nlm.nih.gov/pubmed/35500099 http://dx.doi.org/10.1021/acs.est.2c00223 |
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author | Zhang, Duo Saktrakulkla, Panithi Marek, Rachel F. Lehmler, Hans-Joachim Wang, Kai Thorne, Peter S. Hornbuckle, Keri C. Duffel, Michael W. |
author_facet | Zhang, Duo Saktrakulkla, Panithi Marek, Rachel F. Lehmler, Hans-Joachim Wang, Kai Thorne, Peter S. Hornbuckle, Keri C. Duffel, Michael W. |
author_sort | Zhang, Duo |
collection | PubMed |
description | [Image: see text] Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother–son dyads) in an urban community (East Chicago, Indiana) were analyzed for 74 sulfated metabolites of polychlorinated biphenyls (PCBs). We detected significantly higher mean concentrations of total assessed PCB sulfates in the urban group (110–8900 ng/g fresh weight of serum, mean = 3400 ng/g, standard error = 300) than in the rural cohort (530–6700 ng/g fresh weight of serum, mean = 1800 ng/g, standard error = 500). Eight PCB sulfate congeners (4-PCB 2 sulfate, 4′-PCB 2 sulfate, 2′-PCB 3 sulfate, 4′-PCB 3 sulfate, 4-PCB 11 sulfate, 4′-PCB 18 sulfate, 4′-PCB 25 sulfate, and 4-PCB 52 sulfate) contributed over 90% of the total assessed PCB sulfates in most individuals. The serum samples were enriched in PCB sulfates with fewer than 5 chlorine atoms, and this congener distribution differed from those of PCBs and hydroxylated PCBs in previous studies in the same communities. Regression analysis indicated several significant congener-specific correlations in mother–child dyads, and these relationships differed by location and by mother–daughter or mother–son dyads. This is the first study reporting a broad range of PCB sulfates in populations from urban and rural areas. |
format | Online Article Text |
id | pubmed-9118556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91185562022-05-20 PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities Zhang, Duo Saktrakulkla, Panithi Marek, Rachel F. Lehmler, Hans-Joachim Wang, Kai Thorne, Peter S. Hornbuckle, Keri C. Duffel, Michael W. Environ Sci Technol [Image: see text] Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother–son dyads) in an urban community (East Chicago, Indiana) were analyzed for 74 sulfated metabolites of polychlorinated biphenyls (PCBs). We detected significantly higher mean concentrations of total assessed PCB sulfates in the urban group (110–8900 ng/g fresh weight of serum, mean = 3400 ng/g, standard error = 300) than in the rural cohort (530–6700 ng/g fresh weight of serum, mean = 1800 ng/g, standard error = 500). Eight PCB sulfate congeners (4-PCB 2 sulfate, 4′-PCB 2 sulfate, 2′-PCB 3 sulfate, 4′-PCB 3 sulfate, 4-PCB 11 sulfate, 4′-PCB 18 sulfate, 4′-PCB 25 sulfate, and 4-PCB 52 sulfate) contributed over 90% of the total assessed PCB sulfates in most individuals. The serum samples were enriched in PCB sulfates with fewer than 5 chlorine atoms, and this congener distribution differed from those of PCBs and hydroxylated PCBs in previous studies in the same communities. Regression analysis indicated several significant congener-specific correlations in mother–child dyads, and these relationships differed by location and by mother–daughter or mother–son dyads. This is the first study reporting a broad range of PCB sulfates in populations from urban and rural areas. American Chemical Society 2022-05-02 2022-05-17 /pmc/articles/PMC9118556/ /pubmed/35500099 http://dx.doi.org/10.1021/acs.est.2c00223 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Zhang, Duo Saktrakulkla, Panithi Marek, Rachel F. Lehmler, Hans-Joachim Wang, Kai Thorne, Peter S. Hornbuckle, Keri C. Duffel, Michael W. PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities |
title | PCB
Sulfates in Serum from Mothers and Children in
Urban and Rural U.S. Communities |
title_full | PCB
Sulfates in Serum from Mothers and Children in
Urban and Rural U.S. Communities |
title_fullStr | PCB
Sulfates in Serum from Mothers and Children in
Urban and Rural U.S. Communities |
title_full_unstemmed | PCB
Sulfates in Serum from Mothers and Children in
Urban and Rural U.S. Communities |
title_short | PCB
Sulfates in Serum from Mothers and Children in
Urban and Rural U.S. Communities |
title_sort | pcb
sulfates in serum from mothers and children in
urban and rural u.s. communities |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118556/ https://www.ncbi.nlm.nih.gov/pubmed/35500099 http://dx.doi.org/10.1021/acs.est.2c00223 |
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