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PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities

[Image: see text] Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother–son dyads) in an urban community (East Chicago, Indiana) were analyzed for 74 sulfated metabolites of polychlorin...

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Autores principales: Zhang, Duo, Saktrakulkla, Panithi, Marek, Rachel F., Lehmler, Hans-Joachim, Wang, Kai, Thorne, Peter S., Hornbuckle, Keri C., Duffel, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118556/
https://www.ncbi.nlm.nih.gov/pubmed/35500099
http://dx.doi.org/10.1021/acs.est.2c00223
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author Zhang, Duo
Saktrakulkla, Panithi
Marek, Rachel F.
Lehmler, Hans-Joachim
Wang, Kai
Thorne, Peter S.
Hornbuckle, Keri C.
Duffel, Michael W.
author_facet Zhang, Duo
Saktrakulkla, Panithi
Marek, Rachel F.
Lehmler, Hans-Joachim
Wang, Kai
Thorne, Peter S.
Hornbuckle, Keri C.
Duffel, Michael W.
author_sort Zhang, Duo
collection PubMed
description [Image: see text] Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother–son dyads) in an urban community (East Chicago, Indiana) were analyzed for 74 sulfated metabolites of polychlorinated biphenyls (PCBs). We detected significantly higher mean concentrations of total assessed PCB sulfates in the urban group (110–8900 ng/g fresh weight of serum, mean = 3400 ng/g, standard error = 300) than in the rural cohort (530–6700 ng/g fresh weight of serum, mean = 1800 ng/g, standard error = 500). Eight PCB sulfate congeners (4-PCB 2 sulfate, 4′-PCB 2 sulfate, 2′-PCB 3 sulfate, 4′-PCB 3 sulfate, 4-PCB 11 sulfate, 4′-PCB 18 sulfate, 4′-PCB 25 sulfate, and 4-PCB 52 sulfate) contributed over 90% of the total assessed PCB sulfates in most individuals. The serum samples were enriched in PCB sulfates with fewer than 5 chlorine atoms, and this congener distribution differed from those of PCBs and hydroxylated PCBs in previous studies in the same communities. Regression analysis indicated several significant congener-specific correlations in mother–child dyads, and these relationships differed by location and by mother–daughter or mother–son dyads. This is the first study reporting a broad range of PCB sulfates in populations from urban and rural areas.
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spelling pubmed-91185562022-05-20 PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities Zhang, Duo Saktrakulkla, Panithi Marek, Rachel F. Lehmler, Hans-Joachim Wang, Kai Thorne, Peter S. Hornbuckle, Keri C. Duffel, Michael W. Environ Sci Technol [Image: see text] Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother–son dyads) in an urban community (East Chicago, Indiana) were analyzed for 74 sulfated metabolites of polychlorinated biphenyls (PCBs). We detected significantly higher mean concentrations of total assessed PCB sulfates in the urban group (110–8900 ng/g fresh weight of serum, mean = 3400 ng/g, standard error = 300) than in the rural cohort (530–6700 ng/g fresh weight of serum, mean = 1800 ng/g, standard error = 500). Eight PCB sulfate congeners (4-PCB 2 sulfate, 4′-PCB 2 sulfate, 2′-PCB 3 sulfate, 4′-PCB 3 sulfate, 4-PCB 11 sulfate, 4′-PCB 18 sulfate, 4′-PCB 25 sulfate, and 4-PCB 52 sulfate) contributed over 90% of the total assessed PCB sulfates in most individuals. The serum samples were enriched in PCB sulfates with fewer than 5 chlorine atoms, and this congener distribution differed from those of PCBs and hydroxylated PCBs in previous studies in the same communities. Regression analysis indicated several significant congener-specific correlations in mother–child dyads, and these relationships differed by location and by mother–daughter or mother–son dyads. This is the first study reporting a broad range of PCB sulfates in populations from urban and rural areas. American Chemical Society 2022-05-02 2022-05-17 /pmc/articles/PMC9118556/ /pubmed/35500099 http://dx.doi.org/10.1021/acs.est.2c00223 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Zhang, Duo
Saktrakulkla, Panithi
Marek, Rachel F.
Lehmler, Hans-Joachim
Wang, Kai
Thorne, Peter S.
Hornbuckle, Keri C.
Duffel, Michael W.
PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
title PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
title_full PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
title_fullStr PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
title_full_unstemmed PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
title_short PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities
title_sort pcb sulfates in serum from mothers and children in urban and rural u.s. communities
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118556/
https://www.ncbi.nlm.nih.gov/pubmed/35500099
http://dx.doi.org/10.1021/acs.est.2c00223
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