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Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis

BACKGROUND: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is associated with the response to tumor necrosis factor inhib...

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Detalles Bibliográficos
Autores principales: Julià, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco, Francisco, Erra, Alba, Fernández-Nebro, Antonio, Mas, Antonio Juan, Pérez-García, Carolina, Vivar, Ma Luz García, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Fernandez-Cid, Carlos Marras, Díaz-Torné, César, Moreno, Estefania, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Molina, Jesús Tornero, Marsal, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118662/
https://www.ncbi.nlm.nih.gov/pubmed/35576644
http://dx.doi.org/10.1016/j.ebiom.2022.104053