The potential role of N(7)-methylguanosine (m7G) in cancer

N(7)-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal RNA, mic...

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Autores principales: Luo, Yuejun, Yao, Yuxin, Wu, Peng, Zi, Xiaohui, Sun, Nan, He, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118743/
https://www.ncbi.nlm.nih.gov/pubmed/35590385
http://dx.doi.org/10.1186/s13045-022-01285-5
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author Luo, Yuejun
Yao, Yuxin
Wu, Peng
Zi, Xiaohui
Sun, Nan
He, Jie
author_facet Luo, Yuejun
Yao, Yuxin
Wu, Peng
Zi, Xiaohui
Sun, Nan
He, Jie
author_sort Luo, Yuejun
collection PubMed
description N(7)-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal RNA, microRNA, and transfer RNA. Increasing evidence indicates a critical role for m7G in human disease development, especially cancer, and aberrant m7G levels are closely associated with tumorigenesis and progression via regulation of the expression of multiple oncogenes and tumor suppressor genes. Currently, the underlying molecular mechanisms of m7G modification in cancer are not comprehensively understood. Here, we review the current knowledge regarding the potential function of m7G modifications in cancer and discuss future m7G-related diagnostic and therapeutic strategies.
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spelling pubmed-91187432022-05-20 The potential role of N(7)-methylguanosine (m7G) in cancer Luo, Yuejun Yao, Yuxin Wu, Peng Zi, Xiaohui Sun, Nan He, Jie J Hematol Oncol Review N(7)-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal RNA, microRNA, and transfer RNA. Increasing evidence indicates a critical role for m7G in human disease development, especially cancer, and aberrant m7G levels are closely associated with tumorigenesis and progression via regulation of the expression of multiple oncogenes and tumor suppressor genes. Currently, the underlying molecular mechanisms of m7G modification in cancer are not comprehensively understood. Here, we review the current knowledge regarding the potential function of m7G modifications in cancer and discuss future m7G-related diagnostic and therapeutic strategies. BioMed Central 2022-05-19 /pmc/articles/PMC9118743/ /pubmed/35590385 http://dx.doi.org/10.1186/s13045-022-01285-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Luo, Yuejun
Yao, Yuxin
Wu, Peng
Zi, Xiaohui
Sun, Nan
He, Jie
The potential role of N(7)-methylguanosine (m7G) in cancer
title The potential role of N(7)-methylguanosine (m7G) in cancer
title_full The potential role of N(7)-methylguanosine (m7G) in cancer
title_fullStr The potential role of N(7)-methylguanosine (m7G) in cancer
title_full_unstemmed The potential role of N(7)-methylguanosine (m7G) in cancer
title_short The potential role of N(7)-methylguanosine (m7G) in cancer
title_sort potential role of n(7)-methylguanosine (m7g) in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118743/
https://www.ncbi.nlm.nih.gov/pubmed/35590385
http://dx.doi.org/10.1186/s13045-022-01285-5
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