Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma

PURPOSE: Novel therapeutic targets are critical to unravel for the most common primary brain tumor in adults, glioblastoma (GBM). We have identified a novel synthetic lethal interaction between ClpP activation and HDAC1/2 inhibition that converges on GBM energy metabolism. EXPERIMENTAL DESIGN: Trans...

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Detalles Bibliográficos
Autores principales: Nguyen, Trang T.T., Shang, Enyuan, Schiffgens, Salveena, Torrini, Consuelo, Shu, Chang, Akman, Hasan Orhan, Prabhu, Varun V., Allen, Joshua E., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118753/
https://www.ncbi.nlm.nih.gov/pubmed/35417530
http://dx.doi.org/10.1158/1078-0432.CCR-21-2857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118753/
https://www.ncbi.nlm.nih.gov/pubmed/35417530
http://dx.doi.org/10.1158/1078-0432.CCR-21-2857

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