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Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model

Targeted therapies for epilepsies associated with the mTORC1 signaling negative regulator GATOR1 are lacking. NPRL2 is a subunit of the GATOR1 complex and mutations in GATOR1 subunits, including NPRL2, are associated with epilepsy. To delineate the mechanisms underlying NPRL2-related epilepsies, we...

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Detalles Bibliográficos
Autores principales:	Dentel, Brianne, Angeles-Perez, Lidiette, Ren, Chongyu, Jakkamsetti, Vikram, Holley, Andrew J., Caballero, Daniel, Oh, Emily, Gibson, Jay, Pascual, Juan M., Huber, Kimberly M., Tu, Benjamin P., Tsai, Peter T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118754/ https://www.ncbi.nlm.nih.gov/pubmed/35602938 http://dx.doi.org/10.1016/j.isci.2022.104334

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