Four novel genes associated with longevity found in Cane corso purebred dogs

BACKGROUND: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. RESULTS: SNPs with particular nucleotides were signi...

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Detalles Bibliográficos
Autores principales: Korec, Evžen, Ungrová, Lenka, Hejnar, Jiří, Grieblová, Adéla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118790/
https://www.ncbi.nlm.nih.gov/pubmed/35590325
http://dx.doi.org/10.1186/s12917-022-03290-9
Descripción
Sumario:BACKGROUND: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. RESULTS: SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. CONCLUSIONS: Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03290-9.

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