Four novel genes associated with longevity found in Cane corso purebred dogs

BACKGROUND: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. RESULTS: SNPs with particular nucleotides were signi...

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Autores principales: Korec, Evžen, Ungrová, Lenka, Hejnar, Jiří, Grieblová, Adéla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118790/
https://www.ncbi.nlm.nih.gov/pubmed/35590325
http://dx.doi.org/10.1186/s12917-022-03290-9
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author Korec, Evžen
Ungrová, Lenka
Hejnar, Jiří
Grieblová, Adéla
author_facet Korec, Evžen
Ungrová, Lenka
Hejnar, Jiří
Grieblová, Adéla
author_sort Korec, Evžen
collection PubMed
description BACKGROUND: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. RESULTS: SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. CONCLUSIONS: Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03290-9.
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spelling pubmed-91187902022-05-20 Four novel genes associated with longevity found in Cane corso purebred dogs Korec, Evžen Ungrová, Lenka Hejnar, Jiří Grieblová, Adéla BMC Vet Res Research BACKGROUND: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. RESULTS: SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. CONCLUSIONS: Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03290-9. BioMed Central 2022-05-19 /pmc/articles/PMC9118790/ /pubmed/35590325 http://dx.doi.org/10.1186/s12917-022-03290-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Korec, Evžen
Ungrová, Lenka
Hejnar, Jiří
Grieblová, Adéla
Four novel genes associated with longevity found in Cane corso purebred dogs
title Four novel genes associated with longevity found in Cane corso purebred dogs
title_full Four novel genes associated with longevity found in Cane corso purebred dogs
title_fullStr Four novel genes associated with longevity found in Cane corso purebred dogs
title_full_unstemmed Four novel genes associated with longevity found in Cane corso purebred dogs
title_short Four novel genes associated with longevity found in Cane corso purebred dogs
title_sort four novel genes associated with longevity found in cane corso purebred dogs
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118790/
https://www.ncbi.nlm.nih.gov/pubmed/35590325
http://dx.doi.org/10.1186/s12917-022-03290-9
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