Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming

Escalated innate immunity plays a critical role in SARS-CoV-2 pathology; however, the molecular mechanism is incompletely understood. Thus, we aim to characterize the molecular mechanism by which SARS-CoV-2 Spike protein advances human macrophage (Mϴ) inflammatory and glycolytic phenotypes and uncov...

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Detalles Bibliográficos
Autores principales: Umar, Sadiq, Palasiewicz, Karol, Meyer, Anja, Kumar, Prabhakaran, Prabhakar, Bellur S., Volin, Michael V., Rahat, Rani, Al-Awqati, Mina, Chang, Huan J., Zomorrodi, Ryan K., Rehman, Jalees, Shahrara, Shiva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118817/
https://www.ncbi.nlm.nih.gov/pubmed/35588018
http://dx.doi.org/10.1007/s00018-022-04329-8

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