The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor. m6A can participate in the regulation of tumor immune escape, so as to enhance the monitoring of tumor by the immune system and reduce tum...

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Autores principales: Zhang, Ze, Liu, Furong, Chen, Wei, Liao, Zhibin, Zhang, Wanguang, Zhang, Bixiang, Liang, Huifang, Chu, Liang, Zhang, Zhanguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118853/
https://www.ncbi.nlm.nih.gov/pubmed/35590394
http://dx.doi.org/10.1186/s40164-022-00281-2
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author Zhang, Ze
Liu, Furong
Chen, Wei
Liao, Zhibin
Zhang, Wanguang
Zhang, Bixiang
Liang, Huifang
Chu, Liang
Zhang, Zhanguo
author_facet Zhang, Ze
Liu, Furong
Chen, Wei
Liao, Zhibin
Zhang, Wanguang
Zhang, Bixiang
Liang, Huifang
Chu, Liang
Zhang, Zhanguo
author_sort Zhang, Ze
collection PubMed
description As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor. m6A can participate in the regulation of tumor immune escape, so as to enhance the monitoring of tumor by the immune system and reduce tumorgenesis. m6A can also affect the tumor progression by regulating the immune cell responses to tumor in tumor microenvironment. In addition, immunotherapy has become the most popular method for the treatment of cancer, in which targets such as immune checkpoints are also closely associated with m6A. This review discusses the roles of N6-methyladenosine modification in tumor immune regulation, their regulatory mechanism, and the prospect of immunotherapy. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-91188532022-05-20 The importance of N6-methyladenosine modification in tumor immunity and immunotherapy Zhang, Ze Liu, Furong Chen, Wei Liao, Zhibin Zhang, Wanguang Zhang, Bixiang Liang, Huifang Chu, Liang Zhang, Zhanguo Exp Hematol Oncol Review As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor. m6A can participate in the regulation of tumor immune escape, so as to enhance the monitoring of tumor by the immune system and reduce tumorgenesis. m6A can also affect the tumor progression by regulating the immune cell responses to tumor in tumor microenvironment. In addition, immunotherapy has become the most popular method for the treatment of cancer, in which targets such as immune checkpoints are also closely associated with m6A. This review discusses the roles of N6-methyladenosine modification in tumor immune regulation, their regulatory mechanism, and the prospect of immunotherapy. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-05-19 /pmc/articles/PMC9118853/ /pubmed/35590394 http://dx.doi.org/10.1186/s40164-022-00281-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Ze
Liu, Furong
Chen, Wei
Liao, Zhibin
Zhang, Wanguang
Zhang, Bixiang
Liang, Huifang
Chu, Liang
Zhang, Zhanguo
The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
title The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
title_full The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
title_fullStr The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
title_full_unstemmed The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
title_short The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
title_sort importance of n6-methyladenosine modification in tumor immunity and immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118853/
https://www.ncbi.nlm.nih.gov/pubmed/35590394
http://dx.doi.org/10.1186/s40164-022-00281-2
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