A review on the role of DANCR in the carcinogenesis

DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes expression at post-transcriptional level. In fact, it acts as a molecular sponge for a va...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Baniahmad, Aria, Taheri, Mohammad, Samadian, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118872/
https://www.ncbi.nlm.nih.gov/pubmed/35590326
http://dx.doi.org/10.1186/s12935-022-02612-z
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Baniahmad, Aria
Taheri, Mohammad
Samadian, Mohammad
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Baniahmad, Aria
Taheri, Mohammad
Samadian, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes expression at post-transcriptional level. In fact, it acts as a molecular sponge for a variety of miRNAs, including miR-874-3P, miR-335, miR-149, miR-4319, miR-758-3p, miR-216a-5p, miR-874-3p, miR-33a-5p, miR-335-5p, miR-145-3p, miR-665, miR-345-5p and miR-125b-5p. DANCR also regulates activity of PI3K/AKT/NF-κB, Wnt/β-catenin, ERK/SMAD, MAPK, IL-6/JAK1/STAT3, Smad2/3, p53, FAK/PI3K/AKT/GSK3β/Snail pathways. In the current narrative review article, we summarize the roles of DANCR in the carcinogenesis, with an especial emphasis on its role in the development of osteosarcoma and lung, liver, pancreatic and colorectal cancers.
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spelling pubmed-91188722022-05-20 A review on the role of DANCR in the carcinogenesis Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Baniahmad, Aria Taheri, Mohammad Samadian, Mohammad Cancer Cell Int Review DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes expression at post-transcriptional level. In fact, it acts as a molecular sponge for a variety of miRNAs, including miR-874-3P, miR-335, miR-149, miR-4319, miR-758-3p, miR-216a-5p, miR-874-3p, miR-33a-5p, miR-335-5p, miR-145-3p, miR-665, miR-345-5p and miR-125b-5p. DANCR also regulates activity of PI3K/AKT/NF-κB, Wnt/β-catenin, ERK/SMAD, MAPK, IL-6/JAK1/STAT3, Smad2/3, p53, FAK/PI3K/AKT/GSK3β/Snail pathways. In the current narrative review article, we summarize the roles of DANCR in the carcinogenesis, with an especial emphasis on its role in the development of osteosarcoma and lung, liver, pancreatic and colorectal cancers. BioMed Central 2022-05-19 /pmc/articles/PMC9118872/ /pubmed/35590326 http://dx.doi.org/10.1186/s12935-022-02612-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Baniahmad, Aria
Taheri, Mohammad
Samadian, Mohammad
A review on the role of DANCR in the carcinogenesis
title A review on the role of DANCR in the carcinogenesis
title_full A review on the role of DANCR in the carcinogenesis
title_fullStr A review on the role of DANCR in the carcinogenesis
title_full_unstemmed A review on the role of DANCR in the carcinogenesis
title_short A review on the role of DANCR in the carcinogenesis
title_sort review on the role of dancr in the carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118872/
https://www.ncbi.nlm.nih.gov/pubmed/35590326
http://dx.doi.org/10.1186/s12935-022-02612-z
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