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Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis

BACKGROUND: This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn’s disease and to evaluate whether the number and type of variables included affect the frequency of the outcome. METHODS: MEDLINE [via PubMed], Scopus and Web of Sci...

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Autores principales: Magro, Fernando, Sottomayor, Catarina, Alves, Catarina, Santiago, Mafalda, Ministro, Paula, Lago, Paula, Correia, Luís, Gonçalves, Raquel, Carvalho, Diana, Portela, Francisco, Dias, Cláudia Camila, Dignass, Axel, Danese, Silvio, Peyrin-Biroulet, Laurent, Estevinho, Maria Manuela, Leão Moreira, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118904/
https://www.ncbi.nlm.nih.gov/pubmed/35601803
http://dx.doi.org/10.1177/17562848221092754
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author Magro, Fernando
Sottomayor, Catarina
Alves, Catarina
Santiago, Mafalda
Ministro, Paula
Lago, Paula
Correia, Luís
Gonçalves, Raquel
Carvalho, Diana
Portela, Francisco
Dias, Cláudia Camila
Dignass, Axel
Danese, Silvio
Peyrin-Biroulet, Laurent
Estevinho, Maria Manuela
Leão Moreira, Paula
author_facet Magro, Fernando
Sottomayor, Catarina
Alves, Catarina
Santiago, Mafalda
Ministro, Paula
Lago, Paula
Correia, Luís
Gonçalves, Raquel
Carvalho, Diana
Portela, Francisco
Dias, Cláudia Camila
Dignass, Axel
Danese, Silvio
Peyrin-Biroulet, Laurent
Estevinho, Maria Manuela
Leão Moreira, Paula
author_sort Magro, Fernando
collection PubMed
description BACKGROUND: This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn’s disease and to evaluate whether the number and type of variables included affect the frequency of the outcome. METHODS: MEDLINE [via PubMed], Scopus and Web of Science were searched to identify observational studies that enrolled patients with Crohn’s disease and evaluated a composite or aggregate outcome. The proportion of patients achieving the outcome was determined and a random-effects meta-analysis was performed to evaluate how the frequency of each outcome varies according to the reporting of predefined variables. RESULTS: From 10,257 identified records, 46 were included in the qualitative analysis and 38 in the meta-analysis. The frequency for composite and aggregate outcomes was 0.445 [95% confidence interval (CI): 0.389–0.501] and 0.140 (95% CI: 0.000–0.211), respectively. When comparing composite outcomes by number of included variables, the frequency was 0.271 (95% CI: 0.000–0.405) and 0.698 (95% CI: 0.651–0.746), for one and six variables, respectively. The frequency of the composite outcome varied according to the identity of the variables being reported. Specific pairs of predefined variables had a significant effect in the frequency of composite outcomes. CONCLUSION: Composite outcomes with increasing number of predefined variables show an increase in frequency. Outcomes including variables such as ‘Surgery’ and ‘Steroids’ had higher frequencies when compared with the ones that did not include these variables. These results show that the frequency of composite outcomes is dependent on the number and type of variables being reported.
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spelling pubmed-91189042022-05-20 Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis Magro, Fernando Sottomayor, Catarina Alves, Catarina Santiago, Mafalda Ministro, Paula Lago, Paula Correia, Luís Gonçalves, Raquel Carvalho, Diana Portela, Francisco Dias, Cláudia Camila Dignass, Axel Danese, Silvio Peyrin-Biroulet, Laurent Estevinho, Maria Manuela Leão Moreira, Paula Therap Adv Gastroenterol Original Research BACKGROUND: This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn’s disease and to evaluate whether the number and type of variables included affect the frequency of the outcome. METHODS: MEDLINE [via PubMed], Scopus and Web of Science were searched to identify observational studies that enrolled patients with Crohn’s disease and evaluated a composite or aggregate outcome. The proportion of patients achieving the outcome was determined and a random-effects meta-analysis was performed to evaluate how the frequency of each outcome varies according to the reporting of predefined variables. RESULTS: From 10,257 identified records, 46 were included in the qualitative analysis and 38 in the meta-analysis. The frequency for composite and aggregate outcomes was 0.445 [95% confidence interval (CI): 0.389–0.501] and 0.140 (95% CI: 0.000–0.211), respectively. When comparing composite outcomes by number of included variables, the frequency was 0.271 (95% CI: 0.000–0.405) and 0.698 (95% CI: 0.651–0.746), for one and six variables, respectively. The frequency of the composite outcome varied according to the identity of the variables being reported. Specific pairs of predefined variables had a significant effect in the frequency of composite outcomes. CONCLUSION: Composite outcomes with increasing number of predefined variables show an increase in frequency. Outcomes including variables such as ‘Surgery’ and ‘Steroids’ had higher frequencies when compared with the ones that did not include these variables. These results show that the frequency of composite outcomes is dependent on the number and type of variables being reported. SAGE Publications 2022-05-13 /pmc/articles/PMC9118904/ /pubmed/35601803 http://dx.doi.org/10.1177/17562848221092754 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Magro, Fernando
Sottomayor, Catarina
Alves, Catarina
Santiago, Mafalda
Ministro, Paula
Lago, Paula
Correia, Luís
Gonçalves, Raquel
Carvalho, Diana
Portela, Francisco
Dias, Cláudia Camila
Dignass, Axel
Danese, Silvio
Peyrin-Biroulet, Laurent
Estevinho, Maria Manuela
Leão Moreira, Paula
Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
title Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
title_full Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
title_fullStr Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
title_full_unstemmed Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
title_short Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
title_sort composite outcomes in observational studies of crohn’s disease: a systematic review and meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118904/
https://www.ncbi.nlm.nih.gov/pubmed/35601803
http://dx.doi.org/10.1177/17562848221092754
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