Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands

GPR84 is an immune cell–expressed, proinflammatory receptor currently being assessed as a therapeutic target in conditions including fibrosis and inflammatory bowel disease. Although it was previously shown that the orthosteric GPR84 activators 2-HTP and 6-OAU promoted its interactions with arrestin...

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Detalles Bibliográficos
Autores principales: Marsango, Sara, Ward, Richard J., Jenkins, Laura, Butcher, Adrian J., Al Mahmud, Zobaer, Dwomoh, Louis, Nagel, Falko, Schulz, Stefan, Tikhonova, Irina G., Tobin, Andrew B., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118924/
https://www.ncbi.nlm.nih.gov/pubmed/35427647
http://dx.doi.org/10.1016/j.jbc.2022.101932

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