Antibody-mediated neutralization of SARS-CoV-2

Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prev...

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Autores principales: Gruell, Henning, Vanshylla, Kanika, Weber, Timm, Barnes, Christopher O., Kreer, Christoph, Klein, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118976/
https://www.ncbi.nlm.nih.gov/pubmed/35623355
http://dx.doi.org/10.1016/j.immuni.2022.05.005
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author Gruell, Henning
Vanshylla, Kanika
Weber, Timm
Barnes, Christopher O.
Kreer, Christoph
Klein, Florian
author_facet Gruell, Henning
Vanshylla, Kanika
Weber, Timm
Barnes, Christopher O.
Kreer, Christoph
Klein, Florian
author_sort Gruell, Henning
collection PubMed
description Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.
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spelling pubmed-91189762022-05-19 Antibody-mediated neutralization of SARS-CoV-2 Gruell, Henning Vanshylla, Kanika Weber, Timm Barnes, Christopher O. Kreer, Christoph Klein, Florian Immunity Review Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application. Elsevier Inc. 2022-06-14 2022-05-13 /pmc/articles/PMC9118976/ /pubmed/35623355 http://dx.doi.org/10.1016/j.immuni.2022.05.005 Text en © 2022 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Gruell, Henning
Vanshylla, Kanika
Weber, Timm
Barnes, Christopher O.
Kreer, Christoph
Klein, Florian
Antibody-mediated neutralization of SARS-CoV-2
title Antibody-mediated neutralization of SARS-CoV-2
title_full Antibody-mediated neutralization of SARS-CoV-2
title_fullStr Antibody-mediated neutralization of SARS-CoV-2
title_full_unstemmed Antibody-mediated neutralization of SARS-CoV-2
title_short Antibody-mediated neutralization of SARS-CoV-2
title_sort antibody-mediated neutralization of sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118976/
https://www.ncbi.nlm.nih.gov/pubmed/35623355
http://dx.doi.org/10.1016/j.immuni.2022.05.005
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