Practical genetic control strategies for industrial bioprocesses

Optimization of metabolism to maximize production of bio-based chemicals must consistently balance cellular resources for biocatalyst growth and desired compound synthesis. This mini-review discusses synthetic biology strategies for dynamically controlling expression of genes to enable dual-phase fe...

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Detalles Bibliográficos
Autores principales: Moore, Jonathan C, Ramos, Itzel, Van Dien, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Metabolic Engineering and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118995/
https://www.ncbi.nlm.nih.gov/pubmed/35108392
http://dx.doi.org/10.1093/jimb/kuab088
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author Moore, Jonathan C
Ramos, Itzel
Van Dien, Stephen
author_facet Moore, Jonathan C
Ramos, Itzel
Van Dien, Stephen
author_sort Moore, Jonathan C
collection PubMed
description Optimization of metabolism to maximize production of bio-based chemicals must consistently balance cellular resources for biocatalyst growth and desired compound synthesis. This mini-review discusses synthetic biology strategies for dynamically controlling expression of genes to enable dual-phase fermentations in which growth and production are separated into dedicated phases. Emphasis is placed on practical examples which can be reliably scaled to commercial production with the current state of technology. Recent case studies are presented, and recommendations are provided for environmental signals and genetic control circuits.
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spelling pubmed-91189952022-06-08 Practical genetic control strategies for industrial bioprocesses Moore, Jonathan C Ramos, Itzel Van Dien, Stephen J Ind Microbiol Biotechnol Metabolic Engineering and Synthetic Biology Optimization of metabolism to maximize production of bio-based chemicals must consistently balance cellular resources for biocatalyst growth and desired compound synthesis. This mini-review discusses synthetic biology strategies for dynamically controlling expression of genes to enable dual-phase fermentations in which growth and production are separated into dedicated phases. Emphasis is placed on practical examples which can be reliably scaled to commercial production with the current state of technology. Recent case studies are presented, and recommendations are provided for environmental signals and genetic control circuits. Oxford University Press 2022-02-02 /pmc/articles/PMC9118995/ /pubmed/35108392 http://dx.doi.org/10.1093/jimb/kuab088 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Society of Industrial Microbiology and Biotechnology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Metabolic Engineering and Synthetic Biology
Moore, Jonathan C
Ramos, Itzel
Van Dien, Stephen
Practical genetic control strategies for industrial bioprocesses
title Practical genetic control strategies for industrial bioprocesses
title_full Practical genetic control strategies for industrial bioprocesses
title_fullStr Practical genetic control strategies for industrial bioprocesses
title_full_unstemmed Practical genetic control strategies for industrial bioprocesses
title_short Practical genetic control strategies for industrial bioprocesses
title_sort practical genetic control strategies for industrial bioprocesses
topic Metabolic Engineering and Synthetic Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118995/
https://www.ncbi.nlm.nih.gov/pubmed/35108392
http://dx.doi.org/10.1093/jimb/kuab088
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