Fragile protein folds: sequence and environmental factors affecting the equilibrium of two interconverting, stably folded protein conformations

Recent research on fold-switching metamorphic proteins has revealed some notable exceptions to Anfinsen's hypothesis of protein folding. We have previously described how a single point mutation can enable a well-folded protein domain, one of the two PAS (Per-ARNT-Sim) domains of the human ARNT...

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Detalles Bibliográficos
Autores principales: Xu, Xingjian, Dikiy, Igor, Evans, Matthew R., Marcelino, Leandro P., Gardner, Kevin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119131/
https://www.ncbi.nlm.nih.gov/pubmed/35603043
http://dx.doi.org/10.5194/mr-2-63-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119131/
https://www.ncbi.nlm.nih.gov/pubmed/35603043
http://dx.doi.org/10.5194/mr-2-63-2021

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