Cargando…

Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons

Deciphering the genetic basis of vertebrate craniofacial variation is a longstanding biological problem with broad implications in evolution, development, and human pathology. One of the most stunning examples of craniofacial diversification is the adaptive radiation of birds, in which the beak serv...

Descripción completa

Detalles Bibliográficos
Autores principales: Boer, Elena F., Maclary, Emily T., Shapiro, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119316/
https://www.ncbi.nlm.nih.gov/pubmed/34914861
http://dx.doi.org/10.1111/ede.12395
_version_ 1784710678449225728
author Boer, Elena F.
Maclary, Emily T.
Shapiro, Michael D.
author_facet Boer, Elena F.
Maclary, Emily T.
Shapiro, Michael D.
author_sort Boer, Elena F.
collection PubMed
description Deciphering the genetic basis of vertebrate craniofacial variation is a longstanding biological problem with broad implications in evolution, development, and human pathology. One of the most stunning examples of craniofacial diversification is the adaptive radiation of birds, in which the beak serves essential roles in virtually every aspect of their life histories. The domestic pigeon (Columba livia) provides an exceptional opportunity to study the genetic underpinnings of craniofacial variation because of its unique balance of experimental accessibility and extraordinary phenotypic diversity within a single species. We used traditional and geometric morphometrics to quantify craniofacial variation in an F(2) laboratory cross derived from the straight‐beaked Pomeranian Pouter and curved‐beak Scandaroon pigeon breeds. Using a combination of genome‐wide quantitative trait locus scans and multi‐locus modeling, we identified a set of genetic loci associated with complex shape variation in the craniofacial skeleton, including beak shape, braincase shape, and mandible shape. Some of these loci control coordinated changes between different structures, while others explain variation in the size and shape of specific skull and jaw regions. We find that in domestic pigeons, a complex blend of both independent and coupled genetic effects underlie three‐dimensional craniofacial morphology.
format Online
Article
Text
id pubmed-9119316
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-91193162022-05-19 Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons Boer, Elena F. Maclary, Emily T. Shapiro, Michael D. Evol Dev Editor's Choice Deciphering the genetic basis of vertebrate craniofacial variation is a longstanding biological problem with broad implications in evolution, development, and human pathology. One of the most stunning examples of craniofacial diversification is the adaptive radiation of birds, in which the beak serves essential roles in virtually every aspect of their life histories. The domestic pigeon (Columba livia) provides an exceptional opportunity to study the genetic underpinnings of craniofacial variation because of its unique balance of experimental accessibility and extraordinary phenotypic diversity within a single species. We used traditional and geometric morphometrics to quantify craniofacial variation in an F(2) laboratory cross derived from the straight‐beaked Pomeranian Pouter and curved‐beak Scandaroon pigeon breeds. Using a combination of genome‐wide quantitative trait locus scans and multi‐locus modeling, we identified a set of genetic loci associated with complex shape variation in the craniofacial skeleton, including beak shape, braincase shape, and mandible shape. Some of these loci control coordinated changes between different structures, while others explain variation in the size and shape of specific skull and jaw regions. We find that in domestic pigeons, a complex blend of both independent and coupled genetic effects underlie three‐dimensional craniofacial morphology. John Wiley and Sons Inc. 2021-12-16 2021-11 /pmc/articles/PMC9119316/ /pubmed/34914861 http://dx.doi.org/10.1111/ede.12395 Text en © 2021 The Authors. Evolution & Development published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Editor's Choice
Boer, Elena F.
Maclary, Emily T.
Shapiro, Michael D.
Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
title Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
title_full Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
title_fullStr Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
title_full_unstemmed Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
title_short Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
title_sort complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
topic Editor's Choice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119316/
https://www.ncbi.nlm.nih.gov/pubmed/34914861
http://dx.doi.org/10.1111/ede.12395
work_keys_str_mv AT boerelenaf complexgeneticarchitectureofthreedimensionalcraniofacialshapevariationindomesticpigeons
AT maclaryemilyt complexgeneticarchitectureofthreedimensionalcraniofacialshapevariationindomesticpigeons
AT shapiromichaeld complexgeneticarchitectureofthreedimensionalcraniofacialshapevariationindomesticpigeons